Publications by authors named "S Fragiotta"
Background: This study aimed to analyze the potential pathogenic connection between metabolic factors, photoreceptor cell rearrangements, retinal microvascular perfusion, and functional parameters through multifocal electroretinography (mfERG) in type 1 diabetes mellitus (DM1).
Methods: This prospective observational cohort study enrolled DM1 patients (40.5 ± 9.
In this narrative review we describe the main optical coherence tomography biomarkers appearing in eyes with neovascular age-related macular degeneration (AMD) that do not directly correspond to exudation. We highlight those signs that may mimic exudation and therefore do not require active treatment, such as outer retinal tubulations, pseudocysts, lipid globules, or hyporeflective wedges. Other signs may indicate impending exudation such as hyperreflective foci or shallow irregular retinal pigment epithelium elevation, and therefore should be carefully monitored.
View Article and Find Full Text PDFPurpose: To describe and clarify a possible pathogenetic origin for choroidal caverns in young healthy individuals through a topographical analysis using swept-source optical coherence tomography angiography (SS-OCTA).
Methods: A cross-sectional evaluation of 44 healthy volunteers (44 eyes), aged 20-32 years with no systemic or ocular comorbidities. The topographical analysis of choroidal caverns was performed through a 15 × 15 mm volumetric scan cube using SS-OCTA (PLEX Elite 9000).
Purpose: To assess the sensitivity and specificity of the "triple layer sign" (TLS) (retinal pigment epithelium (RPE), neovascular tissue, and Bruch's membrane) on structural optical coherence tomography (OCT) images for the diagnosis of treatment-naïve non-exudative type-1 macular neovascularization (NE-MNV) in age-related macular degeneration (AMD).
Design: Cross-sectional study.
Methods: Two masked retinal experts evaluated the presence of the TLS in eyes with NE-MNV and controls with an RPE elevation without exudation due to other causes than NE-MNV in AMD [e.
Article Synopsis
- This study focused on characterizing a specific condition called LeptoVitelliform Maculopathy (LVM), which is associated with diffuse choroidal thinning and reticular pseudodrusen, comparing it to other acquired vitelliform lesions (AVL).
- The research involved 56 patients, analyzing differences in lesion size, visual impairment, and structural features like the external limiting membrane and choroidal vascular index.
- Results showed that LVM patients were older, had smaller lesions, and displayed significant structural changes, suggesting that LVM represents a unique phenotype that requires further investigation for prognostic implications.