Publications by authors named "S Fourati"
Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities and their links to various clinical complications, especially long COVID, remains a challenge. In this study, we performed unsupervised subtyping of longitudinal multi-omics immunophenotyping in over 1,000 hospitalized patients, identifying two critical subtypes linked to mortality or mechanical ventilation with prolonged hospital stay and three severe subtypes associated with timely acute recovery.
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- - Our study reveals that HIV infection affects vaccine-induced immunity by reducing the effectiveness of specific CD4 T cells, linked to high levels of inflammatory signals and altered T cell composition.
- - We discovered that the CD4 T cells from HIV-infected individuals show reduced expression of key genes associated with protective immunity from vaccines, along with impaired response pathways for important immune signals like IFNα and IFNγ.
- - Importantly, reducing inflammation in HIV-infected patients using certain drugs improved the immune response of memory CD4 T cells, suggesting that managing inflammation could enhance vaccine efficacy in these individuals.
mRNA vaccines have demonstrated efficacy during the COVID-19 pandemic and are now being investigated for multiple diseases. However, concerns linger about the durability of immune responses, and the high incidence of breakthrough infections among vaccinated individuals highlights the need for improved mRNA vaccines. In this study, we investigated the effects of reinforcing costimulation via 4-1BB, a member of the TNF receptor superfamily, on immune responses elicited by mRNA vaccines.
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