Cardiovascular pharmacology of aqueous extract of the leaves of Bridelia atroviridis Muell. Arg. (Euphorbiaceae) in the rat.

Lyophilised decoction (10%) of the leaves of Bridelia atroviridis Muell. Arg. (Euphorbiaceae) was studied in the rat cardiovascular system.

Study of Costus lucanusianus: plant juice, fraction combinations and pharmacologic estimation of natural product total activity.

The juice of Costus lucanusianus fresh stems was split by chromatography using pharmacological measurements on duodenum and uterus to follow activity. The concentration-effect curves of the parent juice and the active fraction alone or associated with other fractions were analysed according to classical methods used for combination drugs. Results show that the active fraction is potentialised by two groups of fractions which are without intrinsic activity.

The uterotonic action of the aqueous extract of Bridelia atroviridis in the rat.

The effects of the aqueous extract of leaves of Bridelia atroviridis (Bridelia), a small African tree, on the mechanical activity of rat uterus were studied. The aqueous extract of leaves of B atroviridis administered in a concentration-dependent manner (5 x 10(-6)-1.2 x 10(-3) g/ml) induced contractions that were antagonized by various calcium entry blockers (nifedipine, diltiazem, manganese chloride).