Publications by authors named "S Fouad"
Female obesity is a worldwide health issue linked to chronic metabolic low-grade inflammation (metaflammation) causing multiple obesity-related co-morbid conditions. We aimed to assess the serum levels of wingless integration site family member 5 A (Wnt5a), leptin, and tumor necrosis factor-alpha (TNF-α) as markers of obesity-associated metaflammation and investigate the association with toll-like receptors2 (TLR2) gene (Arg753Gln) single nucleotide polymorphism (SNP) among Egyptian females. The study included 60 females with obesity and 30 matched controls.
View Article and Find Full Text PDFBackground: Globally, colorectal cancer (CRC) is among the most prevalent malignant tumors. It is characterized by unlimited proliferation, invasion, and metastasis. MicroRNA-126 (miR-126) has been shown in many studies to play a significant role in CRC, but data regarding its role in CRC Egyptian patients are limited.
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- Cellulite (CLT) is a common cosmetic issue for women, characterized by dimpled skin, and is usually treated with invasive methods like liposuction, but safer topical treatments are preferred.
- This study developed a solid lipid nanoparticle formulation containing caffeine (CA) to enhance its absorption and effectiveness against cellulite, achieving high entrapment efficiency and optimal particle characteristics.
- The final product, CA-SLN-Ngel, demonstrated significant reductions in subcutaneous fat tissue thickness in histological studies, suggesting it could be an effective non-invasive treatment for cellulite.
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- The study explores the growing use of deep learning algorithms in radiology for diagnostic support, emphasizing the need for Explainable AI (XAI) to enhance transparency and trust among healthcare professionals.
- A user study evaluated two visual XAI techniques (Grad-CAM and LIME) in diagnosing pneumonia and COVID-19 from chest images, achieving high accuracy rates of 90% and 98%, respectively.
- Despite generally positive perceptions of XAI systems, participants showed limited awareness of their practical benefits, with Grad-CAM being favored for coherency and trust, though concerns about its usability in clinical settings were noted.
Ubiquitination is a crucial posttranslational modification required for the proper repair of DNA double-strand breaks (DSBs) induced by ionizing radiation (IR). DSBs are mainly repaired through homologous recombination (HR) when template DNA is present and nonhomologous end joining (NHEJ) in its absence. In addition, microhomology-mediated end joining (MMEJ) and single-strand annealing (SSA) provide backup DSBs repair pathways.
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