Publications by authors named "S Forest"
Mortality remains elevated during venoarterial extracorporeal membrane oxygenation support (VA-ECMO) for cardiogenic shock and the role of inflammation is uncertain. By using the neutrophil-to-lymphocyte ratio (NLR), we investigated inflammatory dynamics during VA-ECMO and their relation to clinical outcomes. A single-center, retrospective cohort study was conducted.
View Article and Find Full Text PDFImportance: "Awake" cannulation for venovenous extracorporeal membrane oxygenation (ECMO), where patients remain spontaneously breathing without invasive mechanical ventilation during the cannulation procedure, may reduce lung injury from positive pressure ventilation and promote patient mobility.
Objectives: To examine the association between "awake" cannulation for venovenous ECMO and patient outcomes.
Design, Setting, And Participants: Analysis of the prospectively collected by the multicenter Extracorporeal Life Support Organization registry.
Background: Heart donation after circulatory death (DCD) involves mandatory exposure to warm ischemic injury (WII) due to donor cardiac arrest resulting from withdrawal of life-support (WLS). However, potential DCD donors may also experience a cardiac arrest and undergo cardiopulmonary resuscitation (CPR) and associated WII before WLS. We sought to investigate the effect of previous donor-CPR in DCD heart-transplantation (HT).
View Article and Find Full Text PDFArticle Synopsis
- Despite a record number of heart transplants, there is still a significant shortage of organ donors in the U.S., creating challenges for transplant teams.
- The text discusses barriers to accepting "non-traditional" donor characteristics, such as donors with hepatitis C, cardiac death, COVID-19, HIV, and heart dysfunction.
- The center aims to increase transplant volumes by utilizing medical advancements that enable the acceptance of these non-traditional donors while maintaining positive outcomes.
Introduction: Donation after circulatory death (DCD) donors are becoming an important source of organs for heart-transplantation (HT), but there are limited data regarding their use in multiorgan-HT.
Methods: Between January 2020 and June 2023, we identified 87 adult multiorgan-HTs performed using DCD-donors [77 heart-kidney, 6 heart-lung, 4 heart-liver] and 1494 multiorgan-HTs using donation after brain death (DBD) donors (1141 heart-kidney, 165 heart-lung, 188 heart-liver) in UNOS. For heart-kidney transplantations (the most common multiorgan-HT combination from DCD-donors), we also compared donor/recipient characteristics, and early outcomes, including 6-month mortality using Kaplan-Meier (KM) and Cox hazards-ratio (Cox-HR).