Publications by authors named "S Flores-Martin"
Article Synopsis
- Piscirickettsiosis, caused by the pathogen P. salmonis, significantly impacts the Chilean aquaculture industry, leading to major economic losses, and traditional genotyping methods are limited in cost and expertise requirements.
- This study introduces Loop-mediated Isothermal Amplification (LAMP) as a faster, cheaper, and simpler alternative for diagnosing P. salmonis, developing specific assays for both species identification and differentiation between its genogroups LF-89 and EM-90.
- LAMP assays showed sensitivity and specificity on par with traditional methods while being more suitable for field use, indicating potential for improved disease management and surveillance in salmonid aquaculture.
The innate immune response in , mediated by pattern recognition receptors (PRRs), is crucial for defending against pathogens. This study examined DDX41 protein functions as a cytosolic/nuclear sensor for cyclic dinucleotides, RNA, and DNA from invasive intracellular bacteria. The investigation determined the existence, conservation, and functional expression of the gene in .
View Article and Find Full Text PDFPiscirickettsia salmonis is one of the main pathogens causing considerable economic losses in salmonid farming. The DNA gyrase of several pathogenic bacteria has been the target of choice for antibiotic design and discovery for years, due to its key function during DNA replication. In this study, we carried out a combined in silico and in vitro approach to antibiotic discovery targeting the GyrA subunit of Piscirickettsia salmonis.
View Article and Find Full Text PDFRenibacterium salmoninarum is one of the oldest known fish bacterial pathogens. This Gram-positive bacterium is the causative agent of Bacterial Kidney Disease (BKD), a chronic infection that primarily infects salmonids at low temperatures. Externally, infected fish may show exophthalmos, skin blisters, ulcerations, and hemorrhages at the base of the fins and along the lateral line.
View Article and Find Full Text PDFAliarcobacter butzleri (formerly known as Arcobacter butzleri) is an emerging food-borne zoonotic pathogen that establishes in vitro endosymbiotic relationships with Acanthamoeba castellanii, a free-living amoeba. Previously, we described that this bacterium acts as an endocytobiont of A. castellanii, surviving for at least 10 days in absence of bacterial replication.
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