A covalent organic cage compound acting as a supramolecular shadow mask for the regioselective functionalization of C.

A trigonal-bipyramidal covalent organic cage compound serves as an efficient host to form stable 1 : 1-complexes with C and C. Fullerene encapsulation has been comprehensively studied by NMR and UV/Vis spectroscopy, mass spectrometry as well as single-crystal X-ray diffraction. Exohedral functionalization of encapsulated C threefold Prato reaction revealed high selectivity for the symmetry-matched all--3 addition pattern.

Apocrine glands are bystanders in hidradenitis suppurativa and their involvement is gender specific.

Background: Apocrine glands have been long considered as the initial targeted skin compartment in hidradenitis suppurativa/acne inversa (HS).

Objective: Detection of apocrine gland involvement in HS.

Methods: Apocrine glands were isolated from skin biopsies of involved and uninvolved skin of HS patients (n = 16, females : males 1 : 1) by laser capture microscopy and studied by whole transcriptome profiling.

Infundibular protein and RNA microarray analyses from affected and clinically non-affected scalp in male androgenetic alopecia patients.

Non-invasive sample collection methods could facilitate clinical research on hair diseases. In an exploratory experimental study on six male volunteers with untreated androgenetic alopecia (AGA), Hamilton-Norwood stage IIIv-IV, skin surface and infundibular protein as well as RNA extracts from plucked hair follicles were analyzed from frontal skin, vertex and clinically unaffected occiput. Slightly increased levels of inflammatory markers were only found in AGA-affected scalp skin and infundibulum, not in RNA from plucked hair follicles.

Characterisation of epidermal regeneration in vivo: a 60-day follow-up study.

Objective: To characterise the long-term course of epidermal regeneration in a suction-blister wound model in healthy humans.

Method: A single-centre, prospective cohort study was conducted. Suction blister wounds of 8mm diameter were created on the volar forearms of healthy volunteers.