Publications by authors named "S Ferrari-Lacraz"
Molecular HLA typing techniques are currently undergoing a rapid evolution. While real-time PCR is established as the standard method in tissue typing laboratories regarding allocation of solid organs, next generation sequencing (NGS) for high-resolution HLA typing is becoming indispensable but is not yet suitable for deceased donors. By contrast, high-resolution typing is essential for stem cell transplantation and is increasingly required for questions relating to various disease associations.
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- Genetic and non-genetic factors like graft-versus-host disease and viral infections significantly impact immune reconstitution after hematopoietic stem cell transplantation (HSCT).
- A study of 54 HSCT recipients revealed a noticeable decrease in T-cell receptor (TCR) diversity over time, linked to cytomegalovirus (CMV) reactivation, which altered TCR composition and clonality.
- CMV reactivation led to changes in natural killer (NK) cell populations, increasing certain types while decreasing others, suggesting CMV may promote the growth of specific T and NK cells to help establish a new immune repertoire.
Background: Living donor (LD) kidney transplantation in the setting of ABO blood group incompatibility (ABOi) has been previously reported to be associated with increased risk for antibody-mediated rejection (ABMR). It is however unclear if the presence of pre-transplant donor specific antibodies (DSA) works as an additive risk factor in the setting of ABOi and if DSA positive ABOi transplants have a significantly worse long-term outcome as compared with ABO compatible (ABOc) DSA positive transplants.
Methods: We investigated the effect of pre-transplant DSA in the ABOi and ABOc setting on the risk of antibody-mediated rejection (ABMR) and graft loss in a cohort of 952 LD kidney transplants.
Article Synopsis
- HLA antigen presentation and T-cell mediated immunity are crucial for managing acute viral infections like COVID-19, with the effectiveness linked to the variety of T-cell responses and how well peptides are presented.
- A study analyzed T-cell receptors from 116 healthy individuals and transplant recipients, finding that many possess T-cell sequences capable of recognizing SARS-CoV-2 even without prior exposure.
- The research suggests that genetic factors allow diverse T-cell responses against the virus, potentially explaining why many individuals mount effective immune responses before vaccination, possibly due to mechanisms like heterologous immunity.
Introduction: The type of donation may affect how susceptible a donor kidney is to injury from pre-existing alloimmunity. Many centers are, therefore, reluctant to perform donor specific antibody (DSA) positive transplantations in the setting of donation after circulatory death (DCD). There are, however, no large studies comparing the impact of pre-transplant DSA stratified on donation type in a cohort with a complete virtual cross-match and long-term follow-up of transplant outcome.
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