Crystal structure, Hirshfeld surface analysis and density functional theory study of 1-nonyl-3-phenyl-quinoxalin-2-one.

In the title mol-ecule, CHNO, the phenyl ring is inclined to the quinoxaline ring system at a dihedral angle of 20.40 (9)°. In the crystal, C-H⋯O inter-actions between neighbouring mol-ecules form chains along the -axis direction.

Insights into the crystal structure of two newly synthesized quinoxalines derivatives as potent inhibitor for -Jun -terminal kinases.

Two new compounds namely, ethyl (2E)-3-(dimethylamino)-2-(3-methoxyquinoxalin-2-yl)propen-2-enoate () and ethyl 2-(3-oxo-4-(prop-2-yn-1-yl)-3,4-dihydroquinoxalin-2-yl)-3-phenylpropanoate () have been synthesized from ethyl 2-(oxo-3,4-dihydroquinoxalin-2-yl) acetate (). The compounds were characterized using NMR (H and C), Fourier transform infrared and confirmed by single crystal X-ray diffraction studies. The quinoxaline portion of is almost planar with the substituent containing the dimethylamino and carboxyethyl groups rotated well out of its mean plane.

[Synthesis and pharmacological study of three 1-alkyl-3-(ethoxycarbonylmethylene)-2-oxo quinoxalines].

The acute toxicity study and the psychotropic activity of three alkylated derivatives of 3-(ethoxycarbonylmethylene) -2-oxo quinoxaline did not demonstrate any toxicity of these products at therapeutic dosages. In the animal, these compounds have sedative, myorelaxant and anxiolytic properities.