The effect of individualized education on learning needs of patients undergoing hemodialysis: a randomized controlled clinical trial.

Background: Individualized patient education is one of the new approaches that have attracted much attention in recent years. In line with individualized care, individualized education is designed and implemented based on the learning needs and preferences of each patient. The purpose of this study was to investigate the effect of individualized education on the learning needs of patients on hemodialysis (HD).

Relationship between uncertainty in illness and hope in patients undergoing haemodialysis in Iran: a cross-sectional study.

Objectives: Patients undergoing haemodialysis suffer from uncertainty in illness and hopelessness. The main objective of this study was to examine uncertainty in illness and its relationship with hope in patients undergoing haemodialysis in Iran.

Design: Cross-sectional study.

n-3 polyunsaturated fatty acids enhanced efficacy of cytarabine in iron-overloaded NALM-6 cells via apoptotic and oxidative pathways.

Despite progress in treating acute lymphoblastic leukemia (ALL), the adverse effects of chemotherapy toxicity and iron overload from transfusions continue to affect patients' quality of life. Polyunsaturated fatty acids (PUFAs) exhibit both antitumor and anti-inflammatory properties in leukemia. This study investigated the influence of n-3 PUFA on the efficacy of cytarabine in cells with iron overload.

CSF inflammatory cytokines as prognostic indicators for cognitive decline across Alzheimer's disease spectrum.

Background: A growing body of evidence suggests that neuroinflammation contributes actively to pathophysiology of Alzheimer's disease (AD) and promotes AD progression. The predictive value of neuroinflammatory biomarkers for disease-staging or estimating disease progression is not well understood. In this study, we investigate the diagnostic and prognostic utility of inflammatory biomarkers in combination with conventional AD biomarkers.

Pure LATE-NC: Frequency, clinical impact, and the importance of considering APOE genotype when assessing this and other subtypes of non-Alzheimer's pathologies.

Pure limbic-predominant age-related TDP-43 encephalopathy neuropathologic changes (pure LATE-NC) is a term used to describe brains with LATE-NC but lacking intermediate or severe levels of Alzheimer's disease neuropathologic changes (ADNC). Focusing on pure LATE-NC, we analyzed data from the National Alzheimer's Coordinating Center (NACC) Neuropathology Data Set, comprising clinical and pathological information aggregated from 32 NIH-funded Alzheimer's Disease Research Centers (ADRCs). After excluding subjects dying with unusual conditions, n = 1,926 autopsied subjects were included in the analyses.