Comparison of Race-neutral Versus Race-specific Spirometry Equations for Evaluation of Child Asthma.

Rationale: Race-based estimates of pulmonary function in children could influence the evaluation of asthma in children from racial and ethnic minoritized backgrounds.

Objectives: To determine if race-neutral (GLI-Global) versus race-specific (GLI-Race-Specific) reference equations differentially impact spirometry evaluation of childhood asthma.

Methods: The analysis included 8,719 children aged 5 to <12 years from 27 cohorts across the United States grouped by parent-reported race and ethnicity.

Spatial and temporal determinants of particulate matter peak exposures during pregnancy and early postpartum.

Background: Fine particulate matter (PM) exposure is an important environmental risk for maternal and children's health, with peak exposures especially those derived from primary combustion hypothesized to pose greater risk. Identifying PM peaks and their contributions to personal exposure remains challenging. This study measured personal PM exposure, characterized primary combustion peaks, and investigated their determinants during and after pregnancy and among Hispanic women in Los Angeles, CA.

EV-miRNA associated with environmental air pollution exposures in the MADRES cohort.

Air pollution is a hazardous contaminant, exposure to which has substantial consequences for health during critical periods, such as pregnancy. MicroRNA (miRNA) is an epigenetic mechanism that modulates transcriptome responses to the environment and has been found to change in reaction to air pollution exposure. The data are limited regarding extracellular-vesicle (EV) miRNA variation associated with air pollution exposure during pregnancy and in susceptible populations who may be disproportionately exposed.

Impact of childhood exposure to traffic related air pollution on adult cardiometabolic health: Exploring the role of perceived stress.

Background: Little is known about how childhood exposure to traffic-related air pollution (TRAP) and stress interact to affect adults' cardiometabolic health. We examined this interaction and assessed the impact of over 10 years of childhood TRAP exposure on cardiometabolic health.

Methods: From 2018 to 2023, 313 young adults from the Southern California Children's Health Study were enrolled in a follow-up assessment.

Air quality and wheeze symptoms in a rural children's cohort near a drying saline lake.

Background: In California, climate change and competing water demands are intensifying the desiccation of the Salton Sea, a large land-locked "sea" situated near the southeastern rural US-Mexico border region known as the Imperial Valley.

Methods: To examine the possible effects of living near a saline lake on children's respiratory health, we analyzed the relationship between respiratory health symptoms and ambient PM concentrations among a predominantly Latino/Hispanic cohort of 722 school age children. Guardians completed a survey of their child's wheeze and respiratory health symptoms over the past 12 months, adapted from the International Study of Asthma and Allergies in Childhood (ISAAC).