Publications by authors named "S Farrugia"
Neuroleptic malignant syndrome (NMS) is characterized by hyperthermia, severe rigidity, and autonomic instability that is life-threatening if not treated promptly by intensive supportive care. However, there have been numerous reports of "atypical NMS" where the diagnostic criteria of NMS are only partially satisfied. We present a case of an elderly male who presented with atypical NMS secondary to antidopaminergic drug administration which precipitated acute respiratory failure.
View Article and Find Full Text PDFNodular vasculitis (erythema induratum) associated with systemic minocycline.
Australas J Dermatol
March 2024
Article Synopsis
- A 29-year-old woman experienced painful swelling and nodules on her legs after taking minocycline for acne for 3 years.
- Biochemical tests revealed liver issues and positive antibodies indicative of an autoimmune response, leading to a skin biopsy that confirmed nodular vasculitis.
- After stopping minocycline, her symptoms and liver function improved within 3 months, prompting caution about long-term minocycline use due to its potential to cause nodular vasculitis.
Immune checkpoint inhibitors are increasingly being used to treat various malignancies. Despite their efficacy, they are known to potentially cause immune-related adverse effects, including dermatological manifestations. A rare cutaneous immune-related adverse effect is scleroderma, which has been reported to occur with anti-programmed cell death-1 (PD-1) agents such as pembrolizumab and nivolumab.
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