Identification of the therapeutic potential of novel TIGIT/PVR interaction blockers based advanced computational techniques and experimental validation.

The inhibition of the TIGIT/PVR interaction demonstrates considerable anticancer properties by enhancing the cytotoxic activity of natural killer (NK) and CD8+ T cells. However, the development of small molecule inhibitors that target TIGIT is currently limited. In this study, small molecules with the capacity to bind TIGIT and block the TIGIT/PVR interaction were screened through an advanced computational process, subsequently confirmed by blocking assays.

Novel Self-Healing Superhydrophobic Coating with Oil-Water Separation and Anti-Icing Properties.

A self-healing superhydrophobic coating was successfully prepared in the present work. The coating comprised PEG (polyethylene glycol) and FeO nanoparticles modified with stearic acid (SA) via hydrogen bonds, using polyamide resin and epoxy as binders. The chemically damaged surface could restore its original superhydrophobic structure and chemical composition after 4 h at room temperature or 10 min of heating in an oven with a self-healing efficiency of 95.

Survey of psychological resilience among university students majoring in long-term-care-related disciplines in Taiwan.

Background: The psychological resilience of university students majoring in long-term-care (LTC)-related disciplines is crucial for workforce retention and effective care provision in this field. This study aims to investigate the differences in levels of psychological resilience among these students in Taiwan.

Methods: This cross-sectional study involved 258 participants selected via stratified random sampling from 23 universities across Taiwan from November 2021 to November 2022, representing a diverse educational context.

Clinical Study on the Effects of Total Hip Arthroplasty Assisted by Virtual Planning Combined With Intraoperative Navigation Templates.

Objectives: Although total hip arthroplasty (THA) effectively alleviates pain and restores joint function in the end-stage hip disease, challenges remain in achieving precise osteotomy and minimizing subjective dependency on prosthesis positioning. This study aims to evaluate the efficacy and safety of preoperative virtual planning and navigation templates compared to conventional techniques, providing new methods to enhance the precision and personalization of THA.

Methods: During the period from 2022 to 2023, we conducted a retrospective case-control study on 74 patients who underwent THA surgery at our hospital, based on the inclusion and exclusion criteria.

Catalytic Enantioselective Nucleophilic Amination of α-Halo Carbonyl Compounds with Free Amines.

Catalytic enantioselective substitution of the readily available racemic α-halo carbonyl compounds by nitrogen nucleophiles represents one of the most convenient and direct approaches to access enantioenriched α-amino carbonyl compounds. Distinct from the two available strategies involving radicals and enolate ions, herein we have developed a new protocol featuring an electronically opposite way to weaken/cleave the carbon-halogen bond. A suitable chiral anion-based catalyst enables effective asymmetric control over the key positively charged intermediates.