Long-term outcomes of sequential chemotherapy in epithelioid sarcoma.

Our study was carried out to define the efficacy of treatment with sequential chemotherapy lines in patients with epithelioid sarcoma (ES) at referral centres for sarcoma. From 1998 to 2023, 22 patients with ES were treated with chemotherapy and included in the analysis. The median age at the start of palliative treatment was 35 (20-68).

Real-world outcomes of metastatic clear cell sarcoma sequential chemotherapy.

Clear cell sarcoma is an ultra-rare chemoresistant subtype of soft tissue sarcoma. This retrospective analysis aimed to clarify the efficacy of palliative chemotherapy in CCS by assessing response rates, progression-free survival (PFS), and overall survival (OS) at a referral center. A retrospective analysis of palliative treatment was conducted on patients with CCS treated at the sarcoma unit from 1997 to 2023.

Chemotherapy following immune checkpoint inhibitors in patients with locally advanced or metastatic urothelial carcinoma.

Background: Recent studies suggest improvements in response to salvage chemotherapy (CT) after immune checkpoint inhibitors (ICIs) in several types of cancer. Our objective was to assess the efficacy of chemotherapy re-challenge after ICI, compared with second-line chemotherapy without previous ICI in patients with locally advanced or metastatic urothelial carcinoma (la/mUC).

Methods: In this multicentre retrospective study, we included all patients with la/mUC initiating second or third-line chemotherapy from January 2015 to June 2020.

3D geodynamic-geomorphologic modelling of deformation and exhumation at curved plate boundaries: Implications for the southern Alaskan plate corner.

Plate corners with extreme exhumation rates are important because they offer a perspective for understanding the interactions between tectonics and surface processes. The southern Alaskan margin with its curved convergent plate boundary and associated zones of localized uplift is a prime location to study active orogeny. Here, we present the results of fully-coupled thermo-mechanical (geodynamic) and geomorphologic numerical modelling, the design of which captures the key features of the studied area: subduction of oceanic lithosphere (Pacific plate) is adjacent to a pronounced asymmetric indenter dipping at a shallow angle (Yakutat microplate), which in turn is bounded to the east by a dextral strike-slip shear zone (Fairweather fault).

Treatment of Locally Advanced Merkel Cell Carcinoma-A Multi-Center Study.

Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer with a high risk of recurrence and poor prognosis. The treatment of locally advanced disease involves surgery and radiotherapy. To analyze real-life treatment patterns and clinical outcomes, we conducted a retrospective analysis of data from 161 MCC patients treated with curative intent in four oncological centers in Poland.