A novel approach employing hesitant intuitionistic fuzzy linguistic Einstein aggregation operators within the EDAS approach for multicriteria group decision making.

The Evaluation based on Distance from Average Solution (EDAS) is a multi-criteria decision analysis (MCDA) technique that uses various distances from average values to make decisions. It bears resemblance to other distance-based approaches like SPOTIS, VIKOR or TOPSIS, except that instead of positive and negative ideal solutions, it uses an average solution. For hesitant intuitionistic fuzzy linguistic term sets (HIFLTSs), we first define several operational laws and aggregation operators.

Quinic acid contributes to neurogenesis: Targeting Notch pathway a key player in hippocampus.

Coordinated proliferation and differentiation of neural stem cells (NSCs) results in continuous neurogenesis. The present study provides novel insights into the Notch intracellular signaling in neuronal cell proliferation, maintenance, migration, and differentiation regulated by naturally based Quinic acid (QA) in primary hippocampal cell culture. Further, this study might help in the discovery and development of lead molecules that can overcome the challenges in the treatment of neurodegenerative diseases.

Patuletin Ameliorates Inflammation and Letrozole-Induced Polycystic Ovarian Syndrome in Rats.

Concerns about inflammation-related issues affecting female reproductive health are growing. Chronic low-grade inflammation in women with polycystic ovarian syndrome (PCOS) affects follicular growth, ovulation, and androgen production. The present investigation aimed to elucidate the efficacy of flavonoid patuletin in ameliorating the letrozole-induced PCOS and associated inflammation in rats.

Hippocampal neurogenesis modulated by Quinic acid: A therapeutic strategy for the neurodegenerative disorders.

Neural progenitor cells (NPCs) reside in the brain and participate in the mechanism of neurogenesis that permits the brain to generate the building blocks for enhancement of cognitive abilities and acquisition of new skills. The existence of NPCs in brain has opened a novel dimension of research to explore their potential for treatment of various neurodegenerative disorders. The present study provides novel insights into the intracellular mechanisms in neuronal cells proliferation, maturation and differentiation regulated by Quinic acid (QA).