Publications by authors named "S Fafi-Kremer"
Kidney transplant recipients (KTRs) are highly vulnerable to COVID-19. An intensified scheme of vaccination offers short-term protection to the 50%-75% of KTRs able to develop a germinal center reaction, required for the generation of neutralizing titers of antibodies (NAbs). However, the duration of this vaccinal protection is unknown.
View Article and Find Full Text PDFIn medicine, virological diagnosis is mainly based on the detection of the viral genome and antigens, or on the identification of specific antibodies produced in response to infection. These strategies are suitable for characterizing an active infection or past contact with an already known virus. The recent development of tests for evaluating the host's cellular immune response opens new perspectives for personalized patient care based on immunomonitoring.
View Article and Find Full Text PDFThe MTOR inhibitors have demonstrated antiviral properties, and prior non-randomized studies have suggested they may have a suppressive effect on BKPyV replication. Here, in this randomized, multicenter, controlled trial (BKEVER study), we sought to evaluate the impact of everolimus (EVR) in facilitating the clearance of BKPyV compared to simply reducing immunosuppression among kidney transplant recipients (KTRs). All together, 130 KTRs presenting with BKPyV DNAemia were randomized 1:1 into two groups.
View Article and Find Full Text PDFArticle Synopsis
- Tick-borne encephalitis (TBE) is caused by the TBE virus and typically presents milder symptoms in children, yet there's limited data on its incidence in this age group.* -
- A study at the University Hospital of Strasbourg identified four confirmed cases of TBE among pediatric patients from 2020 to 2022, resulting in an incidence rate of 1.51 cases per 100,000 inhabitants.* -
- The findings emphasize the importance of early diagnosis and follow-up care for affected children, as well as reconsidering vaccination guidelines due to observed cases among unvaccinated patients.*
Article Synopsis
- Tick-borne encephalitis virus (TBEV), spread through tick bites, mostly causes mild illness in over 90% of cases, but can lead to varying degrees of encephalitis in some individuals.
- Around 10% of patients with severe TBE in Austria, Czech Republic, and France have auto-antibodies (auto-Abs) that neutralize certain types of interferon (IFN), which are important for immune response, while only about 1% of patients with milder symptoms have them.
- The presence of these auto-Abs significantly increases the risk of severe TBE, with odds ratios indicating up to a 20.8 times higher chance of severe illness when these auto-Abs are