Assessing the Causal Impact of Social Isolation on Angina Risk: Evidence from a Two-Sample Mendelian Randomization Study.

Introduction: Previous observational studies have indicated an association between social isolation and an increased risk of cardiovascular diseases such as angina, but various factors may confound these studies. This study employs Mendelian randomization to investigate the causal relationship between social isolation and angina, minimizing potential confounding effects.

Methods: We conducted a two-sample Mendelian randomization analysis using genetic variants as instrumental variables for social isolation.

Progress on oxygen-releasing bioactive polymeric scaffolds in tissue engineering and biomedical treatment: A review.

Tissue engineering presents promising avenues for addressing issues related to tissue defects and regenerative medicine. However, the translational efficacy of tissue engineering in clinical settings remains limited, primarily due to the inadequate survival rates of implanted tissue scaffolds. This is attributed to the grafts' inability to adequately supply oxygen and their dependence on the diffusion of oxygen from surrounding tissues for tissue regeneration.

Prenatal Metals and Offspring Cognitive Development: Insights from a Large-Scale Placental Bioassay Study.

The developing foetus is particularly sensitive to neurotoxic metals. The placenta is considered an ideal tissue for biomonitoring prenatal cumulative metal exposure. Based on the Ma'anshan Birth Cohort study (MABC) in China, this study investigated associations of non-essential metals and essential metals in placenta, including arsenic (As), cadmium (Cd), mercury (Hg), lead (Pb), cobalt (Co), selenium (Se) and zinc (Zn), with cognitive development in children among 1586 mother-child pairs.

Association of visceral adiposity index and lipid accumulation product with frailty in U.S. adults: a cross-sectional study from NHANES.

Background: Frailty poses a considerable public health challenge because of its association with negative health consequences. Although obesity is recognized as a contributor to frailty, conventional measures fail to adequately account for the effects of visceral adiposity. The study aimed to investigate the associations between the visceral adiposity index (VAI) or lipid accumulation product (LAP) and frailty.