Publications by authors named "S F Stinson"
Background: Metabolic processes form the basis of the development, functioning and maintenance of the brain. Despite accumulating evidence of the vital role of metabolism in brain health, no study to date has comprehensively investigated the link between circulating markers of metabolic activity and in vivo brain morphology in the general population.
Methods: We performed uni- and multivariate regression on metabolomics and MRI data from 24,940 UK Biobank participants, to estimate the individual and combined associations of 249 circulating metabolic markers with 91 measures of global and regional cortical thickness, surface area and subcortical volume.
Article Synopsis
- Lipid species are being studied as potential biomarkers for cardiometabolic risk in both kids and adults, but how genetics affect these lipids in early life isn't well understood.
- Researchers measured 227 plasma lipid species in nearly 1,150 children and teens to find genetic variants influencing these lipids and their potential links to cardiometabolic issues.
- They discovered significant genetic loci that connect certain lipid species to adult health outcomes, indicating that specific lipids like ceramides and sphingomyelins may have causal relationships with health markers like liver enzymes and blood sugar levels, pointing to long-term risks for cardiometabolic health.
Article Synopsis
- Insulin resistance is a crucial factor in developing cardiometabolic diseases, and while genetic risk scores for it have been validated in adults, their applicability to youth is uncertain.
- A study involving children and adolescents with and without obesity evaluated adult-derived genetic risk scores (GRSs) for insulin resistance, showing significant associations with various cardiometabolic traits.
- The findings indicate that these GRSs could help assess insulin resistance-related cardiometabolic risk in youth if further validated in future studies.
In the Greenlandic Inuit population, 4% are homozygous carriers of a genetic nonsense TBC1D4 p.Arg684Ter variant leading to loss of the muscle-specific isoform of TBC1D4 and an approximately tenfold increased risk of type 2 diabetes. Here we show the metabolic consequences of this variant in four female and four male homozygous carriers and matched controls.
View Article and Find Full Text PDFBackground: Genetics has the potential to inform biologically relevant drug treatment and repurposing which may ultimately improve patient care. In this study, we combine methods which leverage the genetics of psychiatric disorders to prioritize potential drug targets and compounds.
Methods: We used the largest available genome-wide association studies, in European ancestry, of four psychiatric disorders [i.