Publications by authors named "S F Schoch"
Dream function and dream amnesia: Dissolution of an apparent paradox.
Neurosci Biobehav Rev
December 2024
Article Synopsis
- This study examined the effectiveness and reliability of study preregistration in psychology by analyzing 300 research studies to see how closely they followed their preregistered plans.
- The findings revealed that many preregistrations lacked essential methodological details and frequently deviated from their original plans, which suggests that research biases are still possible.
- To enhance the accuracy and utility of preregistration, the authors recommend improved training for researchers, more detailed registration templates, and better transparency in reporting deviations.
Article Synopsis
- Dystroglycan (DG) is a receptor made up of α- and β-DG subunits, and a specific mutation in the β-DG subunit is linked to muscle-eye-brain disease in humans.
- In a mouse model with this mutation, many embryos do not survive to term, but those that do show normal early development but later develop muscle issues and changes in protein localization affecting the blood-brain barrier.
- The mutant mice have reduced levels of DG proteins in muscle and brain, making them a valuable model for studying the effects of β-DG alterations and the underlying mechanisms of a related disease.
To investigate the phosphorylation-based signaling and protein changes occurring early in epileptogenesis, the hippocampi of mice treated with pilocarpine were examined by quantitative mass spectrometry at 4 and 24 h post-status epilepticus at vast depth. Hundreds of posttranscriptional regulatory proteins were the major early targets of increased phosphorylation. At 24 h, many protein level changes were detected and the phosphoproteome continued to be perturbed.
View Article and Find Full Text PDFFull-length RIM1 and 2 are key components of the presynaptic active zone that ubiquitously control excitatory and inhibitory neurotransmitter release. Here, we report that the function of the small RIM isoform RIM4, consisting of a single C2 domain, is strikingly different from that of the long isoforms. RIM4 is dispensable for neurotransmitter release but plays a postsynaptic, cell type-specific role in cerebellar Purkinje cells that is essential for normal motor function.
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