Publications by authors named "S F Pagano"
Background: Osteoporosis (OP) is a metabolic bone disease producing reduction in bone mass with consequent bone fragility. Circular ribonucleic acid (CircRNA) is a form of RNA that forms a loop structure rather than a linear one. CircRNA can be used for therapeutic purposes, including molecular targets or to test new therapies.
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- Turner-type X-linked syndromic intellectual developmental disorder (MRXST) is linked to variants in the HUWE1 gene and manifests through global developmental delays, intellectual disabilities, and unique facial features.
- This study examined two families with MRXST, identifying genetic variations in HUWE1 through whole-exome sequencing and noting different inheritance patterns.
- The research highlights consistent clinical features across cases, emphasizing the role of the HUWE1 gene in development, and proposes a monitoring protocol to improve diagnosis and management for affected individuals.
Metabolic dysfunction-associated fatty liver disease (MASLD) is a common liver and health issue associated with heightened cardiovascular disease (CVD) risk, with Cytokeratin 18 (CK-18) as a marker of liver injury across the MASLD to cirrhosis spectrum. Autoantibodies against apolipoprotein A-1 (AAA-1s) predict increased CVD risk, promoting atherosclerosis and liver steatosis in apoE-/- mice, though their impact on liver inflammation and fibrosis remains unclear. This study examined AAA-1s' impact on low-grade inflammation, liver steatosis, and fibrosis using a MASLD mouse model exposed to AAA-1s passive immunization (PI).
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- People with HIV (PWH) are more susceptible to atherosclerotic cardiovascular disease (ASCVD), making the management of low-density lipoprotein cholesterol (LDL-C) crucial for prevention.
- A study assessed 1,404 PWH aged 40 and over to determine how well their high LDL-C levels were managed according to European Society of Cardiology guidelines, revealing that a significant number were at high risk for ASCVD.
- Results showed that although many participants were at very high or high risk, LDL-C levels were poorly controlled, and only 37% were receiving appropriate lipid-lowering treatment.
SUPRAORBITAL AND ENDONASAL APPROACHES: TAILORING SURGICAL TECHNIQUES FOR TUBERCULUM SELLAE MENINGIOMAS BASED ON PREOPERATIVE GRADING SYSTEMS.
J Neurol Surg A Cent Eur Neurosurg
November 2024
Background Tuberculum sellae meningiomas (TSM) tend to compress the optic apparatus and an ideal surgical route, whether transcranial or endonasal, is still debated. Another issue is if the minimally invasive supraorbital (SO) approach offers the same results compared to the more invasive craniotomy. Aiming to guide approach selection, preoperative grading systems have been described.
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