Longitudinal changes of automated volumetric breast density with postmenopausal hormone therapy.

Objective: To evaluate how volumetric percent density (VPD) changes longitudinally with postmenopausal hormone therapy (HT).

Study Design: Medical records of 297 women who visited the outpatient clinic in a tertiary medical center between 2011 and 2019 were retrospectively reviewed. Study participants were postmenopausal hormone never-users (n = 103), estrogen therapy (ET) users (n = 95), and estrogen plus progestogen (EPT) users (n = 99).

The Effects of Heat Treatment on the Impact Toughness and Fracture of Selective Laser-Melted Corrax Maraging Stainless Steel.

In additive manufacturing (AM) metallic materials, heat treatment (HT) is a common process for modifying the unstable and anisotropic microstructure. Selective laser melting (SLM) Corrax maraging stainless steel is a novel material that has been applied in mold materials with conformal cooling channels in industry. However, the influences of HTs on the various mechanical properties of SLM Corrax steels are still not fully clarified.

Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats.

Thymoquinone (TQ), a bioactive compound derived from black cumin seeds, is renowned for its potent anti-obesity and anti-diabetic properties. Due to the stability challenges of TQ, it has predominantly been utilized in oil formulations. This study aimed to enhance the stability of TQ and investigated the impact of consuming insoluble fiber from black cumin seeds on restoring antioxidant function compromised by diabetes and improving hyperglycemia management.

Protective Effects of Atractylodis Rhizoma Extracts on Lung Injury Induced by Particulate Matter 2.5 in Mice.

This study investigated the lung-protective effects of Atractylodis Rhizoma extracts (the root of Koidz. ex Kitam), known as AJ extracts, in mitigating subacute pulmonary injuries caused by particulate matter 2.5 (PM) exposure in Balb/c mice.

Navigating pharmacokinetic and pharmacodynamics challenges of β-lactam antibiotics in patients with low body weight: efficacy, toxicity, and dosage optimization.

Background: Patients with low body weight (LBW) often exhibit altered pharmacokinetics (PK) in renal clearance and total body water. These changes complicate β-lactam antibiotic dosing, potentially resulting in suboptimal efficacy or increased toxicity.

Objectives: To evaluate the attainment of PK/pharmacodynamic (PD) targets, the prevalence of subtherapeutic and supratherapeutic concentrations, and the incidence of neurotoxicity among LBW patients treated with piperacillin/tazobactam (TZP), cefepime (FEP), and meropenem (MEM).