Publications by authors named "S F Javaid"
Introduction: Inflammatory bowel disease (IBD) is a global health issue profoundly impacting quality of life. The United States accounts for nearly a quarter of the world's IBD patients, with the highest prevalence rates. This study aims to identify the demographic and regional trends of IBD-related mortality in the U.
View Article and Find Full Text PDFThe present study aims to develop a novel thiolated carboxymethyl cellulose (CMC-SH) by the addition of aldehyde groups via oxidation followed by reductive amination and then develop CMC-SH based pH-responsive hydrogel by free radical polymerization approach while assessing its mucoadhesive and permeation-enhancing capabilities. By in-vitro characterization, the intended compound's chemical composition, thermal stability, and amorphous nature were analyzed for CMC-SH polymer. Ellman's assay was utilized to estimate the thiol content and permeation analysis was performed to evaluate its enhanced permeability characteristics.
View Article and Find Full Text PDFBackground: is a multipurpose plant known for its remedial properties but the antimicrobial and hepatoprotective activity of its pods remained unexplored.
Objective: This study aimed to evaluate the antimicrobial and hepatoprotective activity of n-hexane (ANPH) and methanol (ANPM) extracts of pods to scientifically validate their medicinal claims.
Methods: After the pharmacognostic evaluation of pods, tests were carried out to estimate phenolic and flavonoid content and antimicrobial potential.
Article Synopsis
- Plasmodium, the parasite causing malaria, relies on the purine salvage pathway for survival, making its enzymes, like HGXPRT, potential targets for new antimalarial drugs.
- The study focused on inhibiting HGXPRT to disable the parasite's nucleotide synthesis, optimizing assays to evaluate over 200 compounds for their inhibitory effects.
- Fourteen compounds were identified as effective inhibitors, with promising interactions at the enzyme's binding site, and they were shown to be non-toxic to human cells, setting the stage for further drug development.
Background/objectives: Depression, anxiety, and stress are common mental health issues that affect individuals worldwide. This systematic review and meta-analysis examined the effectiveness of various lifestyle interventions including physical activity, dietary changes, and sleep hygiene in reducing the symptoms of depression, anxiety, and stress. Using stress as an outcome and conducting detailed subgroup analyses, this study provides novel insights into the differential effects of lifestyle interventions across diverse populations.
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