Mild Congenital Hyperinsulinism Caused by Mutation in Human Gene.

Congenital hyperinsulinism (CHI) is a rare hereditary disease characterized by the development of hypoglycemia in both infants and adult patients. CHI may be induced by activating mutations in the () gene, which encodes the human glucokinase enzyme. This form of the disease is characterized by considerable phenotypic heterogeneity and may vary in severity of its course.

COMPARATIVE ANALYSIS OF HEPATOPROTECTORS IN WISTAR RATS WITH EXPERIMENTALLY INDUCED METABOLICALLY ASSOCIATED FATTY LIVER DISEASE.

The metabolic syndrome as a consequence of the obesity pandemic resulted in a substantial increase in the prevalence of metabolic-associated fatty live disease (MAFLD) and type 2 diabetes mellitus (T2DM). Because of the similarity in pathobiology shared between T2DM and MAFLD, both disorders coexist in many patients and may potentiate the disease-related outcomes with rapid progression and increased complications of the individual diseases. In fact, awareness about this coexistence and the risk of complications are often overlooked by both hepatologists and diabetologists.

[Laser analyzer as an objective method for evaluating walking parameters in patients with post-stroke disorders].

Objective: To estimate the informativity, sensitivity and specificity of the method of assessing gait function in patients with ataxia and post-stroke hemiparesis using the LA-1 «Laser Analyzer of Kinematic Gait Parameters».

Materials And Methods: Main tempo-rhythm and spatial gait parameters were assessed in groups of healthy people of young (=30) and middle (=30) age. At the second stage, the gait parameters of healthy people were compared with those of patients with ataxia due to vertebrobasilar stroke (=30) and with post-stroke hemiparesis (=30).

[Dynamics of cognitive impairments during L-dopa therapy in Parkinson's disease].

Objective: To assess the dynamics of cognitive impairments (CI) in patients with Parkinson's disease (PD) during L-dopa therapy.

Material And Methods: The randomized clinical study included 41 patients with a refined diagnosis of PD 2.5-3.

[The new approach in the treatment of walking disorders in Parkinson's disease].

Aim: To evaluate the efficacy of a proprietary method based on stimulation of the hindfoot when lifting the foot from the surface of the support and bringing it forward in the treatment of walking disorders in patients with Parkinson's disease (PD).

Material And Methods: The study included 19 patients with walking disorders, akinetic-rigid and mixed form of PD. The stage of the disease on the Hoehn-Yahr scale at the time of the study was 2.