Optically tunable catalytic cancer therapy using enzyme-like chiral plasmonic nanoparticles.

Cascade enzymatic reactions in living organisms are fundamental reaction mechanisms in coordinating various complex biochemical processes such as metabolism, signal transduction, and gene regulation. Many studies have attempted to mimic cascade reactions using nanoparticles with enzyme-like activity; however, precisely tuning each reaction within complex networks to enhance the catalytic activity remains challenging. Here, we present enzyme-like chiral plasmonic nanoparticles for optically tunable catalytic cancer therapy.

Potent inhibition of human monoamine oxidase A and B by phenolic compounds and polyunsaturated fatty acids in tobacco smoke.

Smoking is a main cause of premature death and preventable disease in the world. Interestingly, animal studies indicate that inhibition of monoamine oxidase (MAO), key enzymes for the degradation of neurotransmitters, increased self-administration of nicotine. The purpose of this study was to identify and characterize the potential MAO inhibitors in tobacco smoke responsible for MAO inhibition in smokers.

β-Ionone suppresses colorectal tumorigenesis by activating OR51E2, a potential tumor suppressor.

Background: Olfactory receptors (ORs) are present in non-olfactory tissues and contribute to diverse biological roles beyond smell perception. Among them, OR51E2 has been associated with cancer biology, and its activator, β-ionone, a natural terpenoid, is known to have anticancer effects.

Purpose: This study aimed to clarify the tumor-suppressive role of OR51E2 in colorectal cancer (CRC), unravel the regulatory mechanism underlying its downregulation, and evaluate the therapeutic potential of β-ionone, an OR51E2 ligand, in CRC progression.

An integrated bioaerosol sampler with simultaneous sampling and droplet encapsulation for the monitoring of airborne bacteria.

Monitoring of bioaerosols requires the provision of highly concentrated liquid samples in a short period. Such a bioaerosol sampler should not only be a low-cost, compact device but should also have a technology to achieve a high collection efficiency and concentrated samples in small liquid volumes. In this study, for the first time, we developed a bioaerosol sampler that can simultaneously collect bacteria and highly concentrated liquid samples by combining electrostatic and electrowetting technologies.

Diastolic blood pressure variability predicts adverse outcomes in stabilized acute heart failure patients.

Blood pressure variability; heart failure; Cardiovascular outcome; Diastolic blood pressure.