[Impairment of antiviral cellular resistance and possibilities of its correction during acute altitude hypoxia].

Antiviral cell resistance of blood monocytes and lymphocytes was studied in 29 healthy human subjects subjected to acute altitude hypoxia (AAH) in climatic chamber TABAI, and 39 healthy males during rapid ascent from the sea level up to 3250 m. The antiviral resistance of immune cells was found to be suppressed by AAH. Double blind method was used to compare effects of placebo, dexamethasone and olifen (approved by the Pharmacology Committee of the Russian Ministry of Health as an antihypoxic preparation) on the antiviral resistance of cells during AAH.

[Olifen action on mutagenesis in human lymphocytes].

Antihypoxic drug olifen has been studied for effect in 72-hour PHA-stimulated cultures of blood lymphocytes in 15 healthy donors and 35 patients with diseases accompanied by enhanced mutagenesis in lymphocytes (rheumatoid arthritis, systemic lupus erythematosus, hypophyseal adenoma, neoplasms, chronic intoxications). Olifen has no mutagenic effect on mutagenesis in lymphocytes in a wide dose range. In diseases with intensive mutagenesis in lymphocytes olifen exhibits antimutagenic effect without lymphopoiesis.

[Cytospectrophotometric study of hemoglobin in human erythrocytes. II. Methemoglobin formation in acute hypobaric hypoxia].

The percentage of erthrocytes with thorn-shaped protuberances--echinocytes--was calculated in the blood smears of 10 healthy men before and after a 48 hour sharp hypobaric hypoxia in the climatic chamber of Tabai. The absorbtion spectra at the range 400-650 nm were investigated in the smooth erythrocytes and echinocytes. The methemoglobin content in the echinocytes is higher than in the smooth erythrocytes.

[Lymphopoietic characteristics in acute hypobaric hypoxia].

10 healthy men were examined, that underwent a 48 hours hypobaric (acute) hypoxia in the climate chamber "Tabaĭ", with conditions corresponding to those at an altitude of 4,000 m. The "ascent" and "descent" were performed correspondingly within 30 minutes. Increased share of dying lymphocytes and frequency of chromosomal aberrations in these were found in addition to an elevated activity of nucleolar organizers and to changed morphological patterns of argentophilic nucleoli.