Publications by authors named "S F Cook"
Article Synopsis
- Peutz-Jeghers syndrome (PJS) is linked to early-onset gastrointestinal polyps due to mutations in the STK11 gene, and managing these polyps requires constant monitoring since there are no preventive treatments.
- Research using mouse models has identified a specific type of fibroblast, called polyp-enriched crypt top fibroblasts (pCTFs), that contributes to polyp formation, with a similar transcriptional signature found in PJS patient polyps.
- The study highlights interleukin 11 (IL-11) as a crucial factor in the progression of PJS by promoting fibroblast reprogramming and presents IL-11 as a potential therapeutic target to reduce polyp development.
Pityriasis rubra pilaris (PRP) is a rare dermatologic disorder marked by erythema, scaling, pruritus, pain, and follicular hyperkeratosis. It usually appears as red, scaly patches with areas of unaffected skin and is commonly associated with orange-colored palms and soles. While the exact etiology is unknown, emerging evidence points to several contributing factors.
View Article and Find Full Text PDFDyspnea is a complex symptom with diverse etiologies, primarily cardiopulmonary. Initial evaluation requires a structured approach to exclude life-threatening causes such as pneumothorax, pulmonary embolism, or acute heart failure. Detailed anamnesis, clinical examination, and targeted diagnostic tests, including NT-proBNP levels, ECG, and thoracic imaging, are essential for accurate assessment.
View Article and Find Full Text PDFBackground: Drug-eluting stents (DESs) have become the gold standard of coronary angioplasty since their inception in 2002. Biodegradable polymer DESs (BP-DESs) have been postulated to be superior to durable polymer DESs (DP-DESs) due to their more biocompatible polymer. To date, no study has shown the superiority of one type of polymer compared with the other.
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