Publications by authors named "S F Chiew"
The human epidermal growth factor receptor 2 (HER2) gene is a critical biomarker for determining amplification status and targeting clinical therapies in breast cancer treatment. This study introduces a computer-aided method that automatically measures and scores HER2 gene status from invasive tissue regions of breast cancer using whole slide images (WSI) through silver hybridization (SISH) staining. Image processing and deep learning techniques are employed to isolate untruncated and non-overlapping single nuclei from cancer regions.
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- Triple-negative breast cancer (TNBC) is challenging to treat due to poor prognosis and lack of effective therapies; targeting PD-L1 may offer potential benefits.
- A study in Malaysia involved 138 advanced TNBC patients, assessing PD-L1 positivity using tissue samples.
- Results showed 37.7% had positive PD-L1 expression, with a notable association between PD-L1 positivity and resected tumor samples.
Article Synopsis
- Fluorescence in situ hybridization (FISH) is the standard method for checking HER2 status in breast cancer, but it has downsides like needing special training and facing signal degradation; an alternative method, silver-enhanced in situ hybridization (SISH), offers a more durable solution for analysis via bright-field microscopy.* -
- This study introduces a novel deep learning approach to classify Normal, Amplified, and Non-Amplified regions in HER2-SISH whole slide images, aiming to improve accuracy over traditional methods.* -
- Using a private dataset, the researchers achieved a striking 99.9% patch-level accuracy and an average accuracy of 98% through k-fold cross-validation, suggesting that this deep
Amyloid diseases are characterized by the accumulation of misfolded protein aggregates in human tissues, pose significant challenges for both diagnosis and treatment. Protein aggregations known as amyloids are linked to several neurodegenerative conditions including Alzheimer's disease, Parkinson's disease, and systemic amyloidosis. The key goal of this research is to employ Small-Angle X-ray Scattering (SAXS) to examine the supramolecular structures of amyloid aggregates in human tissues.
View Article and Find Full Text PDFRecent advancements in medical imaging have greatly enhanced the application of computational techniques in digital pathology, particularly for the classification of breast cancer using in situ hybridization (ISH) imaging. HER2 amplification, a key prognostic marker in 20-25% of breast cancers, can be assessed through alterations in gene copy number or protein expression. However, challenges persist due to the heterogeneity of nuclear regions and complexities in cancer biomarker detection.
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