Publications by authors named "S F Chaney"
Age-related macular degeneration (AMD), a complex neurodegenerative disease, is a leading cause of visual impairment worldwide with a strong genetic component. Genetic studies have identified several loci, but few causal genes with functional characterization. Here we highlight multiple lines of evidence which show a causal role in AMD for SLC16A8, which encodes MCT3, a retinal pigment epithelium (RPE) specific lactate transporter.
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- Viruses in a specific subfamily can significantly impact captive snakes, with documented infections primarily found in certain snake families, causing either no symptoms or respiratory/oral diseases.
- A study began in June 2019 that screened 165 confiscated snakes for serpentovirus; 56% tested positive, with infections found in various species from Asia, Africa, South America, and one from Australia.
- Clinical signs of infection included weight loss, abnormal behavior, and respiratory issues, with postmortem results showing severe inflammation and necrosis; this research highlights the need for serpentovirus screening in captive snake populations.
Background: For more than a century, scientists have tried to find the key to causation of mental ill health in heredity and genetics. The difficulty of finding clear and actionable answers in our genes has not stopped them looking. This history offers important context to understanding mental health science today.
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- Rare changes in certain genes can cause eye problems that affect vision early on, but we don’t fully understand how this happens.
- Researchers noticed that a specific gene, called DRAM2, is found in many parts of the eye, and when it’s not working properly, it can lead to issues in different types of eye cells.
- Studying human eye cells and mice showed that when DRAM2 is missing, it can cause some cells to grow too much while other important cells start to die off, making eye diseases more complicated to understand.
Childhood vaccines are a safe, effective, and essential component of any comprehensive public health system. Successful and complete child immunization requires sensitivity and responsiveness to community needs and concerns while reducing barriers to access and providing respectful quality services. Community demand for immunization is influenced by multiple complex factors, involving attitudes, trust, and the dynamic relationship between caregivers and health workers.
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