Exploring public support for novel tobacco and alcohol control policies in Great Britain 2021-2023: A population-based cross-sectional survey.

Objective And Rationale: This study assessed support for novel tobacco compared with alcohol control policies among adults in Great Britain in 2021-2023. Objectives were to assess 1) overall level of support for tobacco compared to alcohol control policies; 2) level of support for tobacco compared to alcohol control policies among people who smoke tobacco or who consume alcohol at increasing and higher risk levels, or who do both; 3) level of support for tobacco compared to alcohol control policies among different sociodemographic groups?

Methods: Data were collected in September/October 2021-2023 in a monthly population-based survey on smoking and drinking behaviour of adults across Great Britain (N = 6311), weighted to match the overall population. Outcome measure was level of support for each seven tobacco and alcohol control policies.

First-Line Chemo-Immunotherapy in SCLC: Outcomes of a Binational Real-World Study.

Introduction: SCLC is characterized by aggressiveness and limited treatment options, especially in extensive-stage SCLC (ES-SCLC). Immunotherapy added to the platinum-etoposide combination has recently become standard in this setting. This retrospective study aims to evaluate the real-world effectiveness of chemo-immunotherapy in patients with ES-SCLC, focusing on subpopulations excluded from clinical trials.

Health and economic impact of oral PrEP provision across subgroups in western Kenya: a modelling analysis.

Introduction: Oral pre-exposure prophylaxis (PrEP) is a priority intervention for scale-up in countries with high HIV prevalence. Policymakers must decide how to optimise PrEP allocation to maximise health benefits within limited budgets. We assessed the health and economic impact of PrEP scale-up among different subgroups and regions in western Kenya.

Designing dicationic organic salts and ionic liquids exhibiting high fluorescence in the solid state.

Dicationic ionic liquids (DILs) are emerging as a powerful, next-generation approach to designing applied ILs because of their superior physicochemical properties as well as their diverse complexity and tunability for task specific applications. DILs are scarce in the literature compared to monocationic ILs (MILs), and one of their main issues is their expected tendency to possess higher melting temperatures. A series of 1,4-bis[2-(4-pyridyl)ethenyl] benzene and 1,4-bis[2-(2-pyridyl)ethenyl]benzene quaternary salts (Q-BPEBs) with different counterions (bromide, tosylate, and triflimide) and carbon chain lengths (C, C, and C) have been synthesized for their potential as DILs with strong photoluminescent properties in the solid state.

Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles.

In this paper, we attempt to answer two questions: 1) which regions of the human brain, in terms of morphometry, are most strongly related to individual differences in domain-general cognitive functioning ( )? and 2) what are the underlying neurobiological properties of those regions? We meta-analyse vertex-wise -cortical morphometry (volume, surface area, thickness, curvature and sulcal depth) associations using data from 3 cohorts: the UK Biobank (UKB), Generation Scotland (GenScot), and the Lothian Birth Cohort 1936 (LBC1936), with the meta-analytic = 38,379 (age range = 44 to 84 years old). These morphometry associations vary in magnitude and direction across the cortex (|β| range = -0.12 to 0.