[Retinoprotective effects of Retinalamin studied in an experimental model of photochemical damage to rabbit retinas].

Unlabelled: Purpose - to investigate functional and morphological effects of peptide bioregulator (Retinalamin) in modeling of photochemical damage to rabbit retina.

Material And Methods: The study was conducted on 36 rabbits (72 eyes) randomized into 4 equal groups: two experimental groups received parabulbar injections of Retinalamin («Geropharm», Russia) in each eye in dosages of 0.25 mg/kg in a course of 10 days starting from day 1 and day 10 of the experiment, respectively, and two control groups that received injections of normal solution with the same regimen.

Modeling of Retinal Degeneration.

We developed a model of retinal degeneration in rabbits based on exposure to light with a wavelength of 405 nm. This model allows reproducing structural and functional disorders in the central parts of the retina, including primarily degeneration of the outer layers of the retina (retinal pigment epithelium and layer of photoreceptor cells), and is designed to study the mechanisms of formation, progression and effectiveness of new drugs and methods of treatment of degenerative diseases of the retina.

[Multifocal electroretinography in the study of focal and diffuse damage to the rabbit retina].

Purpose: To evaluate the possibility of using the system "Neuro-ERG" (with a module for multifocal ERG) in the study of focal and diffuse pathology in laboratory animals (rabbits).

Material And Methods: Focal retinal damage was modelled in 5 eyes of 5 rabbits by singular laser pulses (532 nm, 100 ms, power 30, 60, 100, 150 and 200 mW) and diffuse retinal damage was modelled in 5 eyes of 5 rabbits by exposure to polychromatic light for 14 days (9500 lm, 6400 K, 230 mW/cm2, 8 h/day). The pair of eyes and areas of intact retina in the eyes with focal retinal damage were used for control.

[Acute ocular lesions after exposure to electromagnetic radiation of ultrahigh frequency (an experimental study)].

Purpose: To investigate the clinical and morphological manifestations of ocular lesions resulting from acute exposure to microwave radiation (MR).

Material And Methods: Twenty-four rabbits were included in the study and divided into four equal groups according to MR exposure time (15, 30, 45, 60 s). The right eyes of rabbits were exposed to MR of 3.

[Mirizzi syndrome management (in Russian only)].

Aim: To assess an effectiveness of complex preoperative diagnosis, conservative treatment, minimally invasive biliary decompression for Mirizzi syndrome and to analyze surgical outcomes depending on the effectiveness of minimally invasive biliary decompression.

Material And Methods: There were 67 patients with Mirizzi syndrome aged 27-96 years (mean age -64.8 years).