Publications by authors named "S Ezzikouri"
To assess the impact of the SARS-CoV-2 booster dose on the immune response against COVID-19, we conducted a cross-sectional study in the Casablanca-Settat region of Morocco. The study included 2,802 participants from 16 provinces, all of whom had received three doses of a SARS-CoV-2 vaccine. IgG antibodies targeting the S1 RBD subunit of the SARS-CoV-2 spike protein were quantified using the SARS-CoV-2 IgG II Quant assay and measured on the Abbott Architect i2000SR instrument.
View Article and Find Full Text PDFThe human immunodeficiency virus (HIV), a retrovirus targeting the immune system and the primary agent causing acquired immunodeficiency syndrome (AIDS), can have fatal consequences. Although antiretroviral treatment has significantly reduced mortality and comorbidity in people living with HIV (PLHIV), its impact on metabolic syndrome (MetS) remains notable. Several genome-wide association studies have identified a link between the gene () and MetS, particularly in type 2 diabetes.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how genetic variations in the IFIH1 gene relate to COVID-19 susceptibility and severity among Moroccans, highlighting the importance of genetic factors in immune response to the virus.
- Results showed that the TT genotype of the rs1990760 variant is linked to higher susceptibility to COVID-19, while the CT genotype appears to offer protective benefits against both infection and severe disease.
- No significant association was found with another variant, rs3747517, indicating that not all genetic factors play a role in COVID-19 outcomes.
Report of SARS-CoV-2 JN.1 variant in Morocco.
Microbiol Resour Announc
September 2024
Article Synopsis
- - The study identifies the JN.1 variant of SARS-CoV-2 in Morocco through genomic sequencing.
- - Four clinical samples were analyzed, including nasopharyngeal swabs from one female and three male patients.
- - The Illumina COVIDSeq Test was utilized for a thorough genomic analysis of the samples.
Background: Nucleotide-binding oligomerization domain 1 (NOD1) and NOD2 are involved in carcinogenic processes by recognizing bacterial cell wall components and triggering inflammation. This study explored the association between genetic variations in NOD1 and NOD2 and susceptibility to hepatocellular carcinoma (HCC) and its progression in a Moroccan population.
Methods: Genotyping of NOD1 rs2075820 (C>T) and NOD2 rs718226 (A>G) was performed using the TaqMan allelic discrimination assay in 467 Moroccan individuals.