Publications by authors named "S Eyre"
Psoriasis (Ps) is a debilitating immune-mediated chronic skin condition. It affects about 1-3% of the world population, with an 8-11% prevalence in Northern European populations. Tyrosine kinase 2 (TYK2) is a newly identified target for Ps.
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- * Researchers developed models using T cells to analyze how different forms of IL23R (wild type vs. protective mutant) impact the signaling pathway via STAT3, identifying genes related to psoriasis risk through RNA sequencing.
- * The study discovered several key genes (like HLA-B, SOCS1, and CCR5) that are differentially regulated based on IL23R form, contributing to a better understanding of the IL23 pathway and its role in psoriasis.
The importance of functional genomics studies in precision rheumatology.
Best Pract Res Clin Rheumatol
December 2024
Rheumatic diseases, those that affect the musculoskeletal system, cause significant morbidity. Among risk factors of these diseases is a significant genetic component. Recent advances in high-throughput omics techniques now allow a comprehensive profiling of patients at a genetic level through genome-wide association studies.
View Article and Find Full Text PDFObjective: Juvenile idiopathic arthritis (JIA)-associated uveitis (JIAU) is a serious JIA comorbidity that can result in vision impairment. This study aimed to identify genetic risk factors within the major histocompatibility complex for JIAU and evaluate their contribution for improving risk classification when combined with clinical risk factors.
Methods: Data on single nucleotide polymorphisms, amino acids, and classical HLA alleles were available for 2,497 patients with JIA without uveitis and 579 patients with JIAU (female 2,060, male 1,015).