Non-invasive cerebral autoregulation monitoring during paediatric cardiac surgery without cardiopulmonary bypass requiring intraoperative cross-clamping of one of the carotid arteries.

Introduction: Neurologic complications remain one of the major risks after pediatric cardiac surgery. Cerebral autoregulation (CA) is a physiologic mechanism regulating cerebral perfusion. A dynamic intraoperative evaluation can possibly detect the impairment of the cerebral regulatory function during surgery.

Mechanistic insights into complement pathway inhibition by CR1 domain duplication.

Complement receptor 1 (CR1) is a membrane glycoprotein with a highly duplicated domain structure able to bind multiple ligands such as C3b and C4b, the activated fragments of complement components C3 and C4, respectively. We have previously used our knowledge of this domain structure to identify CSL040, a soluble extracellular fragment of CR1 containing the long homologous repeat (LHR) domains A, B, and C. CSL040 retains the ability to bind both C3b and C4b but is also a more potent complement inhibitor than other recombinant CR1-based therapeutics.

Effects of measured and simulated diffraction from a plate on sound source localization.

In daily life, natural or man-made structures influence sound propagation, causing reflections and diffraction with potential effects on auditory spatial perception. While the effect of isolated reflections on binaural localization has been investigated, consequences of edge diffraction on spatial perception have received less attention. Here, effects of edge diffraction on the horizontal localization of a sound source were assessed when a flat square plate occludes the direct sound or produces a reflection in an otherwise anechoic environment.

Rate dependent neural responses of interaural-time-difference cues in fine-structure and envelope.

Advancements in cochlear implants (CIs) have led to a significant increase in bilateral CI users, especially among children. Yet, most bilateral CI users do not fully achieve the intended binaural benefit due to potential limitations in signal processing and/or surgical implant positioning. One crucial auditory cue that normal hearing (NH) listeners can benefit from is the interaural time difference (ITD), .

Corrigendum: Spectral and binaural loudness summation of equally loud narrowband signals in single-sided-deafness and bilateral cochlear implant users.

[This corrects the article DOI: 10.3389/fnins.2022.