Publications by authors named "S Etman"

Non-small cell lung cancer (NSCLC) is characterized by high recurrence rates in the early stages. In a German cohort, recurrence-free survival after 5 years was 62% (stage IA1), 40.7% (stage IIA) and 28% (stage IIIA).

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Article Synopsis
  • - Pancreatic cancer is difficult to treat due to its poor blood supply and dense tissue, and current chemotherapy options are limited.
  • - Quinacrine, a repositioned drug with anticancer properties, can be delivered more effectively using novel nanoparticles made from natural fucoidan, enhanced by adding lactoferrin as a targeting ligand.
  • - The dual-targeted nanoparticles demonstrated a significant increase in anticancer effectiveness, reducing tumor volume by 68% and enhancing animal survival without causing liver toxicity, suggesting they could be a promising treatment for pancreatic cancer.
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Quinacrine is an antimalarial drug that was repositioned for treatment of cancer. This is the first work to enhance quinacrine activity and minimize its associated hepatotoxicity via loading into bio-degradable, bio-renewable lignosulfonate nanoparticles. Particles were appraised for treatment of pancreatic cancer, one of the most life-threatening tumors with a five-year survival estimate.

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Fucoidan is a marine polymer extracted from diverse types of brown algae. This polysaccharide showed great potential towards treatment of different types of cancer. In this study, the activity of fucoidan extracted from Undaria Pinnatifida was investigated against pancreatic cancer (one of the most life-threatening cancers).

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Fucoidan is an edible algae that has long been used as part of east Asians' diet. Recently, various pharmacological activities of the polymer have been discovered including its ability to act as antimicrobial, anti-thrombotic, antiviral, anti-inflammatory and anti-cancer. This review is the first to focus on the anti-cancer ability of this biopolymer and factors affecting it.

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