Publications by authors named "S Essig"
Article Synopsis
- The medial frontal cortex (mFC) and locus coeruleus (LC) are brain regions linked to cognitive functions like attention, memory, and decision-making, yet their molecular regulators remain unclear.
- Using chemogenetic stimulation in mice, the study found that activating LC neurons targeting the mFC led to increased gene transcription, especially in GABAergic neurons related to cognitive functions.
- The research highlights the role of specific gene expression as potential biomarkers for neuropsychiatric disorders like ADHD, schizophrenia, and Alzheimer's, aiming to inform treatments for cognitive and behavioral symptoms.
. Osteoarticular infections (OI) in children cause considerable morbidity with associated long-lasting sequelae. Comprehensive data in Mongolian children are missing.
View Article and Find Full Text PDFApolipoprotein E (ApoE) is a protein that is important for lipid storage, transport, and metabolism. gene variants are associated with Alzheimer's disease (AD), as well as attentional function in healthy humans. Previous research has shown that transcription is increased following stimulation of the pathway between the locus coeruleus (LC) and frontal cortex (FC) in mice.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers used chemogenetics and RNA-sequencing to explore how stimulating the locus coeruleus affects gene expression in the frontal cortex, finding increased transcription of a specific gene.
- * Further investigations revealed that this gene's expression, which could influence attention-related behaviors, is particularly prominent in GABAergic neurons and varies by sex, suggesting potential therapeutic targets for attention disorders like ADHD, schizophrenia, and Alzheimer's disease.
Background: Diagnostic ultrasound has become a bedside tool widely available to many primary care physicians (PCPs) in Europe. It is often used as point-of-care ultrasonography (POCUS) in this setting. In Switzerland, certain POCUS examinations are listed as learning objectives in existing ultrasound training programs (we defined these examinations as swissPOCUS = sPOCUS).
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