The emerging role of circular RNAs in cisplatin resistance in ovarian cancer: From molecular mechanism to future potential.

Ovarian cancer (OC) is the most common cause of death in female cancers. The prognosis of OC is very poor due to delayed diagnosis and identification of most patients in advanced stages, metastasis, recurrence, and resistance to chemotherapy. As chemotherapy with platinum-based drugs such as cisplatin (DDP) is the main treatment in most OC cases, resistance to DDP is an important obstacle to achieving satisfactory therapeutic efficacy.

The potential role of circular RNAs -regulated PI3K signaling in non-small cell lung cancer: Molecular insights and clinical perspective.

Non-small cell lung cancer (NSCLC), accounting for more than 80% of all cases, is the predominant form of lung cancer and the leading cause of cancer-related deaths worldwide. Significant progress has been made in diagnostic techniques, surgical interventions, chemotherapy protocols, and targeted therapies at the molecular level, leading to enhanced treatment outcomes in patients with NSCLC. Extensive evidence supports the use of circular RNAs (circRNAs), a specific category of naturally occurring non-coding small RNAs (ncRNAs), for the diagnosis, monitoring of treatment efficacy, and assessment of survival in NSCLC.

Effectiveness of Group Psychosexual Training for Marital Adjustment and Sexual Self-Efficacy of Infertile Women: A Randomized Controlled Trial.

Infertility can be associated with unfavorable psychological consequences such as a sense of marital incompatibility and sexual inadequacy. To address these issues, this study aimed to assess the effectiveness of group psycho-sexual training in improving marital adjustment and sexual self-efficacy of infertile women. A randomized controlled clinical trial (RCT) study was conducted in Babol, Iran, with 72 infertile women, randomly assigned to either the intervention group (n = 36) or the control group (n = 36).

Vitamin D receptor expression in sperm of males with unexplained infertility.

Background: Vitamin D is associated with numerous disorders, including infertility. Accordingly, the goal of this research was to find out the level of vitamin D and messenger RNA (mRNA) expression of vitamin D receptor (VDR) in the sperm of male subjects with unexplained infertility.

Methods: Twenty-four unexplained infertile men as the case group and 22 healthy fertile men as the control group were recruited.

Optimization of nickel selenide for hydrogen and oxygen evolution reactions by response surface methodology.

In this study, the electrocatalytic activity of Ni-Se electrode synthesized on nickel foam by pulse electrodeposition was optimized through the design of experiments (DOE) approach using the response surface methodology (RSM) for both hydrogen and oxygen evolution reactions. The frequency (f), duty cycle (dc), current density (i), and electrodeposition time (sum of ts) were chosen as the parameters of the pulse electrodeposition method. The analyses of variance (ANOVA) were performed on the responses of the designed experiments that included the required overpotential at the current density of 10 mA/cm for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) (η and η), active surface area (R) and intrinsic electrocatalytic activity (i/R).