Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation.

High mitochondrial DNA (mtDNA) amount has been reported to be beneficial for resistance and recovery of metabolic stress, while increased mtDNA synthesis activity can drive aging signs. The intriguing contrast of these two mtDNA boosting outcomes prompted us to jointly elevate mtDNA amount and frequency of replication in mice. We report that high activity of mtDNA synthesis inhibits perinatal metabolic maturation of the heart.

Based on the Real-Life Data of Türkiye; Comparison of Anatomical and Functional Outcomes of Phakic and Pseudophakic Patients in Wet Type Age-Related Macular Degeneration.

Objectives: The aim of the study was comparison of wet-type age-related macular degeneration in phakic and pseudophakic patients in terms of anatomical and functional success based on the real-life data of Türkiye.

Methods: The multicenter retrospective real-life study data of the. retinal study group were used in this study.

Results of anti-VEGF treatment for neovascular AMD in eyes with different baseline visual acuity in Turkish population-based on real life data-Bosphorus retina study group.

Background: To investigate the anatomical and visual outcomes of the patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (anti-VEGF), according to the baseline best-corrected visual acuity (BCVA) based on the multicenter real-life data.

Methods: Five-hundred-ninety patients who had taken the Pro Re Nata (PRN) treatment regimen with three loading doses and at least one year of follow-up were included. The patients were divided into three groups according to the baseline BCVA: Group 1 (BCVA ≥ 1.

Comparison of Heat Transfer Through Various Fixed Prosthetic Materials During Grinding.

Purpose: To measure and compare the mean temperature values due to heat generated during the grinding of different prosthetic materials with diamond burs using a high-speed instrument with and without water cooling.

Materials And Methods: In total, 120 disk-shaped specimens (10 × 2 mm), each with a smaller disk in the center (3 × 2 mm), were fabricated from yttrium-stabilized zirconia, monolithic zirconia, glass-ceramic, indirect composite, polyetheretherketone (PEEK), and cast metal (Ni-Cr alloy). The specimens were divided into six groups (n = 20) according to material type.

The inpatient costs related to revascularization of lower extremity artery disease in terms of amputation and mortality rates.

Objective: With the initial utilization of endovascular treatment options in 1970s, the number of procedures performed for lower extremity artery disease (LEAD) both with open surgical (OS) and endovascular (EV) treatment increased, but this did not result in a decrease in the number of amputations. The burden of LEAD still constitutes a huge proportion among the health care costs over the world.

Methods: The patients who admitted to our clinic between October 2014 and December 2019 with LEAD and required revascularization were enrolled.