Publications by authors named "S Eppenberger-Castori"

Article Synopsis
  • Histological assessment of autoimmune hepatitis (AIH) is difficult, particularly with nonclassical features like bile-duct injury being understudied.
  • Researchers developed an AI tool, called AI(H), to analyze liver biopsy slides from patients with AIH, using 123 pre-treatment biopsies for training.
  • The AI models demonstrated high accuracy in detecting various features related to AIH, including tissue structures and immune cells, offering a more detailed and reproducible assessment compared to manual analysis.
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Introduction: The clinical course of prostate cancer (PCa) is highly variable, ranging from indolent behavior to rapid metastatic progression. The Gleason score is widely accepted as the primary histologic assessment tool with significant prognostic value. However, additional biomarkers are required to better stratify patients, particularly those at intermediate risk.

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Colorectal cancer (CRC) is a leading cause of cancer-associated death. In the tumor site, the interplay between effector immune cells and cancer cells determines the balance between tumor elimination or outgrowth. We discovered that the protein TMEM123 is over-expressed in tumour-infiltrating CD4 and CD8 T lymphocytes and it contributes to their effector phenotype.

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Background: The disruption of epithelial features represents a critical step during breast cancer spread. In this context, the dysregulation of desmosomal proteins has been associated with malignant progression and metastasis formation. Curiously, both tumour suppressive and pro-metastatic roles have been attributed to desmosomal structures in different cancer entities.

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