Hypertension as predictive factor for bevacizumab-containing first-line therapy in metastatic breast and colorectal cancer in BRECOL (GEICAM/2011-04) study.

Background: Retrospective data suggest an association between bevacizumab efficacy and the incidence of arterial hypertension (AHT). Additionally, epigenetic mechanisms have been related to AHT.

Methods: This prospective observational study conducted by GEICAM Spanish Breast Cancer Research Group included metastatic breast (MBC) or colorectal (mCRC) cancer patients treated with bevacizumab-containing chemotherapy as first-line treatment.

Aerobic Visible-Light-Driven Borylation of Heteroarenes in a Gel Nanoreactor.

Heteroarene boronate esters constitute valuable intermediates in modern organic synthesis. As building blocks, they can be further applied to the synthesis of new materials, since they can be easily transformed into any other functional group. Efforts toward novel and efficient strategies for their preparation are clearly desirable.

Transient absorption spectroscopic studies on 4-nitroquinoline N-oxide: From femtoseconds to microseconds timescale.

The singlet excited state of 4-nitroquinoline N-oxide (NQNO*) has been characterized by different spectroscopic techniques, combining transient absorption with steady state and time-resolved emission spectroscopy. The energy of NQNO* has been established as 255 kJ/mol from the fluorescence spectrum, whereas its lifetime has been found to be 10 ps in the femto-laser flash photolysis (LFP) experiments, where a characteristic SS absorption band with maximum centered at 425 nm is observed. In a first stage, the triplet excited state of NQNO (NQNO*) has also been characterized by emission spectroscopy in solid matrix, at low temperature.

Pesticide Residues in Commercial Lettuce, Onion, and Potato Samples From Bolivia-A Threat to Public Health?

Bolivia does not have a surveillance program for pesticide residues in food. The few published studies have suggested that pesticide contamination in food may present a public health problem. Data are lacking for all foods except tomatoes and breast milk.

Solar filters as feasible acceptors of atomic oxygen.

The triazine derivative Tinosorb S has been shown to accept atomic oxygen generated by N-oxide photodeoxygenation. This is a unique example of a solar filter and mechanism-directed antioxidant. The concept has been proved by a combination of steady-state and laser-flash photolysis.