Obesity, inflammation and resting energy expenditure: possible mechanism of progranulin in this pathway.

Aim: The aim of the study was to measure circulating PGRN levels and to investigate its potential correlation with resting metabolic rate and obesity related complications. Moreover, to investigate on the PGRN and some important gene expressions in energy expenditure in vitro in samples of PBMCs derived from all participants of our study in a cellular model.

Methods: Of the 163 participants who were recruited for the current cross-sectional study, 37 (22.