Publications by authors named "S Elshaer"
Background: Colorectal cancer (CRC) is a major public health concern. Animal models play a crucial role in understanding the disease pathology and development of effective treatment strategies. Chemically induced CRC represents a cornerstone in animal model development; however, due to the presence of different animal species with different genetic backgrounds, it becomes mandatory to study the susceptibility of different mice species to CRC induction by different chemical entities such as 1,2-dimethylhydrazine (DMH).
View Article and Find Full Text PDFColorectal cancer (CRC) is the third most prevalent cancer worldwide. While chemotherapy remains the standard treatment approach, natural products have emerged as a promising alternative. Among these, apigenin, a natural flavonoid, has garnered significant attention due to its pro-oxidant and antioxidant properties in various types of cancer.
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- Despite advancements in targeted therapies, breast cancer remains a serious health risk for women, highlighting the need for ongoing research.
- The rise of transcriptomics through high-throughput sequencing has shed light on the important roles of non-coding RNAs, especially long non-coding RNAs (lncRNAs), in disease development, including cancer.
- The review focuses on recent findings about lncRNAs in breast cancer, particularly their involvement in key pathways like PI3K, MAPK, NF-kB, and hypoxia, along with their mechanisms of resistance in cancer biology.
Article Synopsis
- Breast cancer (BC) is the most common cancer in women worldwide, characterized by high heterogeneity, treatment resistance, and risks of recurrence and metastasis.
- Early detection and continuous monitoring are essential for improving survival rates, but the lack of precise biomarkers significantly affects patients' quality of life.
- Recent studies highlight the role of long noncoding RNAs (lncRNAs) in understanding and managing BC, particularly in relation to specific signaling pathways and potential therapeutic strategies.
Purpose: Diabetic macular edema (DME) is the primary cause of vision impairment in diabetic retinopathy (DR) patients. A previous study has shown the efficacy of montelukast, a cysteinyl leukotriene receptor (CysLTR)1 antagonist, in a diabetic mouse model. This study aims to understand the CysLTR1 signaling in retinal endothelial cells and the impact of montelukast.
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