Publications by authors named "S El-Heis"
We previously reported that a combined -inositol, probiotics, and enriched micronutrient supplement (intervention) taken preconception and in pregnancy reduced postpartum blood loss (PBL) and major postpartum hemorrhage compared with a standard micronutrient supplement (control), as secondary outcomes of the NiPPeR trial. This study aimed to identify the intervention components that may contribute to this effect. Associations of plasma concentrations of -inositol and vitamins B2, B6, B12, and D at preconception (before and after supplementation), early (~7-weeks), and late pregnancy (~28-weeks) with PBL were assessed by multiple linear regression, adjusting for site, ethnicity, preconception BMI, parity, and previous cesarean section.
View Article and Find Full Text PDFObservational studies have reported associations between nutrition during pregnancy and mental wellbeing. As secondary outcomes, the NiPPeR double-blind randomized trial in women planning conception investigated whether a myo-inositol, probiotics and enriched micronutrients formulation (intervention) taken preconception and throughout pregnancy could improve mental wellbeing during pregnancy and post-delivery, compared with a standard micronutrient supplement (control). Mood and anxiety symptoms were ascertained (Edinburgh Postnatal Depression Scale (EPDS), State-Trait Anxiety Inventory (STAI-state)) at preconception (baseline), 7, 28 and 34 weeks gestation, 3-weeks and 6-months post-delivery.
View Article and Find Full Text PDFArticle Synopsis
- The study looked at how taking a supplement called myo-inositol early in pregnancy affects blood sugar levels in pregnant women.
- They found that having higher levels of myo-inositol at 7 weeks helped with blood sugar after eating, but it didn’t really lower the risk of diabetes during pregnancy or impact baby’s weight.
- The results suggested that starting myo-inositol earlier might help some women, but not everyone, and it varied by different ethnic groups.
Background: Nutritional intervention preconception and throughout pregnancy has been proposed as an approach to promoting healthy postnatal weight gain in the offspring but few randomised trials have examined this.
Methods: Measurements of weight and length were obtained at multiple time points from birth to 2 years among 576 offspring of women randomised to receive preconception and antenatally either a supplement containing myo-inositol, probiotics, and additional micronutrients (intervention) or a standard micronutrient supplement (control). We examined the influence on age- and sex-standardised BMI at 2 years (WHO standards, adjusting for study site, sex, maternal parity, smoking and pre-pregnancy BMI, and gestational age), together with the change in weight, length, BMI from birth, and weight gain trajectories using latent class growth analysis.
Article Synopsis
- Maternal vitamin status before and during pregnancy significantly impacts pregnancy outcomes and offspring development, but there is limited longitudinal data on how it changes from preconception through postpartum.
- The NiPPeR trial involved 1,729 women who were randomized to receive either a standard or enhanced vitamin supplement from preconception to 6 months postpartum, evaluating the effects on vitamin status and glucose tolerance during pregnancy.
- Key findings focused on the primary outcome of glucose tolerance at 28 weeks and a secondary outcome related to reducing maternal micronutrient insufficiencies in vitamins B6, B12, riboflavin, and D during pregnancy.