Publications by authors named "S El-Dika"

Background And Aims: Direct endoscopic necrosectomy (DEN) is a recommended strategy for treatment of walled-off necrosis (WON). DEN uses a variety of devices including the EndoRotor (Interscope, Inc, Northbridge, Mass, USA) debridement catheter. Recently, a 5.

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Despite the increasing rate of detection of incidental pancreatic cystic lesions (PCLs), current standard-of-care methods for their diagnosis and risk stratification remain inadequate. Intraductal papillary mucinous neoplasms (IPMNs) are the most prevalent PCLs. The existing modalities, including endoscopic ultrasound and cyst fluid analysis, only achieve accuracy rates of 65-75% in identifying carcinoma or high-grade dysplasia in IPMNs.

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Video 1The major papilla was cannulated with a sphincterotome over a straight wire. The polypoid saccular structures were identified by cholangioscopy.

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Pancreatic cystic lesions are being discovered as incidental lesions during cross-sectional imaging studies of the abdomen with increasing frequency. Endoscopic ultrasound is an important diagnostic modality for managing pancreatic cystic lesions. There are various types of pancreatic cystic lesions, from benign to malignant.

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Article Synopsis
  • This study aimed to prospectively evaluate the effectiveness of next-generation sequencing (NGS) on pancreatic cyst fluid in a multi-institutional setting, as previous research had mainly been retrospective or focused on single hospitals.
  • In total, 1933 pancreatic cyst specimens were tested, with 98% being satisfactory for NGS analysis, and findings were correlated with current guidelines and surgical outcomes.
  • Results indicated that mutations such as GNAS had high sensitivity and specificity for diagnosing mucinous cysts and that combining genomic alterations with cytopathologic evaluation significantly improved diagnostic accuracy compared to existing guidelines.
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