Publications by authors named "S El Mazouz"
Introduction: Follicular helper T cells are essential for helping in the maturation of B cells and the production of neutralizing antibodies (NAbs) during primary viral infections. However, their role during recall responses is unclear. Here, we used hepatitis C virus (HCV) reinfection in humans as a model to study the recall collaborative interaction between circulating CD4 T follicular helper cells (cTfh) and memory B cells (MBCs) leading to the generation of NAbs.
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- Deep dermatophytosis is a serious skin infection caused by fungi called Dermatophytes, which can lead to various complications, including deeper skin issues and widespread infections.
- A case report details a 23-year-old man with scarring alopecia and subcutaneous abscesses, diagnosed with a severe form of dermatophytosis caused by Trichophyton Rubrum.
- The patient had a mutation in the CARD9 gene, a risk factor identified in the Mediterranean, and after surgery to drain the abscesses and antifungal treatment, he recovered well.
Schwannomas are the most common benign tumors of the peripheral nerves, but represents only 5%-8% of all soft tissue tumors. Their diagnosis is usually delayed due to their slow growth and the nervous adaptation to their increased volume. Ultrasound sonography and magnetic resonance imaging (MRI) images usually ease the diagnosis.
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- Successive infections with hepatitis C virus (HCV) allow researchers to study the body's protective immune response and improve vaccine development.
- A study analyzed blood samples from eight individuals who naturally recovered from two HCV infections, revealing specific immune signatures linked to successful reinfection control.
- Findings showed that both antibodies and T cells play a crucial role in eliminating HCV reinfection, highlighting the need for future vaccines that can activate both immune responses.
Macrophages are key regulators of inflammation and repair, but their heterogeneity and multiple roles in the liver are not fully understood. We aimed herein to map the intrahepatic macrophage populations and their function(s) during acute liver injury. We used flow cytometry, gene expression analysis, multiplex-immunofluorescence, 3D-reconstruction, and spatial image analysis to characterize the intrahepatic immune landscape in mice post-CCl-induced acute liver injury during three distinct phases: necroinflammation, and early and late repair.
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