Publications by authors named "S El Hajjar"
Cancer treatment has been rapidly transformed by the development of immune checkpoint inhibitors targeting CTLA-4 and PD-1/PD-L1. However, many patients fail to respond, especially those with an immunosuppressive tumor microenvironment (TME), suggesting the existence of additional immune checkpoints that act through orthogonal mechanisms. Sialic acid-binding immunoglobulin-like lectin (Siglec)-7 and -9 are newly designated glycoimmune checkpoints that are abundantly expressed by tumor-infiltrating myeloid cells.
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- Epilepsy is a neurological disorder that causes unpredictable seizures, increasing health risks for patients.
- The study introduces a novel method called Deep Embedded Gaussian Mixture (DEGM) for detecting seizures through EEG data, combining deep learning techniques with clustering algorithms.
- Results show DEGM significantly improves seizure detection performance on large datasets, offering better outcomes for patients and advancing research in this area.
An interosseous ganglion cyst is a very rare entity, found mostly in skeletally mature patients, particularly in long bones such as the tibia and femur. However, we are the first to report here an unusual case of interosseous ganglion cyst of the upper ribs in a young female patient, which she had an unpredicted presentation of cough and hemoptysis and a large painful lump over the anterior left upper chest. The radiological and pathological workup confirmed the presence of a benign interosseous ganglion cyst arising from the left first rib, invading the second rib and the apex of the left lung.
View Article and Find Full Text PDFObjectives: To investigate the incidence rate, clinical characteristics across different age groups, antimicrobial susceptibility, and outcomes of () infections.
Methods: A retrospective analysis was carried out to include 66 cases with confirmed cultures from sterile samples between January 2014 and June 2022 at King Faisal Specialist Hospital and Research Centre in Riyadh, Saudi Arabia.
Results: A total of 66 cases were identified, with an incidence rate of 0.
Article Synopsis
- Inflammation is crucial for defense but has negative effects on bodily functions, and how it is monitored is not fully understood.
- Acidic tissue environments are linked to inflammation, and this research shows that macrophages can detect acidic pH to adjust their inflammatory responses.
- The study identifies BRD4 as a pH sensor in macrophages, and highlights the role of intracellular acidification in regulating gene transcription related to inflammation, suggesting a mechanism for controlling the inflammatory response.