A toddler with severe vitamin D-dependent rickets type 1 A (VDDR1A), hungry bone syndrome, and severe RSV infection: presentation and therapeutic challenges.

Background: Vitamin D-dependent rickets type 1 A (VDDR1A) is an autosomal recessive disorder due to mutations in the CYP27B1 gene which result in inability to generate 1,25(OH)D.

Case Presentation: An 18-month-old boy with VDDR1A presented with hypotonia and respiratory distress. He had been diagnosed 2 months earlier, having been evaluated for stunted growth, hypotonia, and delayed developmental milestones.

Quantum self-consistent equation-of-motion method for computing molecular excitation energies, ionization potentials, and electron affinities on a quantum computer.

Near-term quantum computers are expected to facilitate material and chemical research through accurate molecular simulations. Several developments have already shown that accurate ground-state energies for small molecules can be evaluated on present-day quantum devices. Although electronically excited states play a vital role in chemical processes and applications, the search for a reliable and practical approach for routine excited-state calculations on near-term quantum devices is ongoing.

Symmetry Breaking Slows Convergence of the ADAPT Variational Quantum Eigensolver.

Because quantum simulation of molecular systems is expected to provide the strongest advantage over classical computing methods for systems exhibiting strong electron correlation, it is critical that the performance of VQEs be assessed for strongly correlated systems. For classical simulation, strong correlation often results in symmetry breaking of the Hartree-Fock reference, leading to Löwdin's well-known "symmetry dilemma", whereby accuracy in the energy can be increased by breaking spin or spatial symmetries. Here, we explore the impact of symmetry breaking on the performance of ADAPT-VQE using two strongly correlated systems: (i) the "fermionized" anisotropic Heisenberg model, where the anisotropy parameter controls the correlation in the system, and (ii) symmetrically stretched linear H, where correlation increases with increasing H-H separation.

Post Laparoscopy Neuropathic Pain Treated by Capsaicin 8% Dermal Patch.

We report a case of chronic left flank neuropathic pain after a renal cyst removal in a 54-year old female. The patient was treated with a single application of capsaicin 8% dermal patch, with satisfactory results at an eight week follow up visit. Capsaicin 8% dermal patch could be a suitable alternative in the conservative management of post laparoscopy neuropathic pain, as it can be effective and has a well-tolerated safety profile.