Publications by authors named "S E van Roeden"

Q fever is a worldwide zoonosis due to Coxiella burnetii, responsible for endocarditis and endovascular infections. Since the 1990s, the combination hydroxychloroquine + doxycycline has constituted the curative and prophylactic treatment in persistent focalized Q fever. This combination appears to have significantly reduced the treatment's duration (from 60 to 26 months), yet substantial evidence of effectiveness remains lacking.

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Background: A causative role of Coxiella burnetii (the causative agent of Q fever) in the pathogenesis of B-cell non-Hodgkin lymphoma (NHL) has been suggested, although supporting studies show conflicting evidence. We assessed whether this association is present by performing a detailed analysis on the risk of mature B-cell NHL after Q fever during and after the largest Q fever outbreak reported worldwide in the entire Dutch population over a 16-year period.

Methods: We performed an ecological analysis.

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Objectives: The COVID-19 pandemic pressurised healthcare with increased shortage of care. This resulted in an increase of awareness for code status documentation (ie, whether limitations to specific life-sustaining treatments are in place), both in the medical field and in public media. However, it is unknown whether the increased awareness changed the prevalence and content of code status documentation for COVID-19 patients.

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Article Synopsis
  • The study investigates the effectiveness of different lock solutions (taurolidine and citrate) in preventing infection and malfunction of central venous catheters (CVCs) in hemodialysis patients.
  • A total of 1514 patients were analyzed, revealing that taurolidine-based solutions significantly reduced the need for CVC removal due to infection or malfunction compared to citrate-based solutions.
  • Although taurolidine showed better results, the study's retrospective nature means its findings should be interpreted carefully, and no definitive conclusions about the superiority of one solution over another can be made.
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