Dynamic ultrasound-based modeling predictive of response to neoadjuvant chemotherapy in patients with early breast cancer.

Early prediction of patient responses to neoadjuvant chemotherapy (NACT) is essential for the precision treatment of early breast cancer (EBC). Therefore, this study aims to noninvasively and early predict pathological complete response (pCR). We used dynamic ultrasound (US) imaging changes acquired during NACT, along with clinicopathological features, to create a nomogram and construct a machine learning model.

Lake pulses driven by glacier melting and climate variability.

The Tibetan Plateau is home to numerous glaciers that are important for freshwater supply and climate regulation. These glaciers, which are highly sensitive to climatic variations, serve as vital indicators of climate change. Understanding glacier-fed hydrological systems is essential for predicting water availability and formulating climate adaptation strategies.

Research on correlation analysis and multivariate nonlinear regression modeling method for the tensile properties of mugwort petiole.

The defoliation quality of mugwort defoliation equipment is an important factor to measure the defoliation efficiency, and the tensile properties of mugwort petiole will have an impact on the defoliation quality, such as the crushing rate and the abscission rate. In order to reduce the crushing rate and improve the abscission rate during mechanical harvesting of mugwort leaves, the tensile properties of mugwort petiole need to be studied. The tensile properties of mugwort petiole are closely related to its macroscopic and microscopic physicochemical parameters.

Numerical simulation study on the influence of bend diameter rate on the flow characteristics of nature gas hydrate particles.

Bend pipe is a common part of long distance pipeline. There is very important to study the flow law of hydrate particles in the bend pipe, and pipeline design will be optimized. In addition, the efficiency and safety of pipeline gas transmission will be improved.

The survival of B cells is compromised in kidney disease.

Antibody-mediated protection against pathogens is crucial to a healthy life. However, the recent SARS-CoV-2 pandemic has shown that pre-existing comorbid conditions including kidney disease account for compromised humoral immunity to infections. Individuals with kidney disease are not only susceptible to infections but also exhibit poor vaccine-induced antibody response.