Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.

Quiescent leukemic cells survive chemotherapy, with translation changes. Our data reveal that FXR1, a protein amplified in several aggressive cancers, is elevated in quiescent and chemo-treated leukemic cells and promotes chemosurvival. This suggests undiscovered roles for this RNA- and ribosome-associated protein in chemosurvival.

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling.

Bone remodeling is a tightly regulated process that is required for skeletal growth and repair as well as adapting to changes in the mechanical environment. During this process, mechanosensitive osteocytes regulate the opposing responses between the catabolic osteoclasts and anabolic osteoblasts. To better understand the highly intricate signaling pathways that regulate this process, our lab has developed a foundationary lab-on-a-chip (LOC) platform for analyzing functional outcomes (formation and resorption) of bone remodeling within a small scale system.

mC modification of mRNA serves a DNA damage code to promote homologous recombination.

Recruitment of DNA repair proteins to DNA damage sites is a critical step for DNA repair. Post-translational modifications of proteins at DNA damage sites serve as DNA damage codes to recruit specific DNA repair factors. Here, we show that mRNA is locally modified by mC at sites of DNA damage.

Bone remodeling platforms: Understanding the need for multicellular lab-on-a-chip systems and predictive agent-based models.

The purpose of this paper is to emphasize the need for more complex bone remodeling platforms that allow for investigations of intricate multicellular interactions that regulate this process. We discuss the efforts we have taken to develop lab-on-a-chip systems for bone remodeling and the motivation for pursuing more advanced multicellular models. Further, we discuss mathematical modeling opportunities that will allow experimental results to extend beyond the set laboratory conditions.