Solvent-controlled solid-state phase transitions of a heterospin Cu(II) complex with imidazolyl-substituted nitronyl nitroxide.

Spontaneous solvent-controlled solid-state transformations were observed for a series of polymeric chain solvates [Cu(hfac)L]·0.5Solv (Solv = (CH)CO, THF, CHCl, CHBr, CHCl) with 2-(1-propyl-1-imidazol-5-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1-imidazole-3-oxide-1-oxyl (L) under ambient conditions. The conversion of powdered polymeric chain [Cu(hfac)L]·0.

Pyridyl-Substituted Nitronyl Nitroxides: Comprehensive Magnetochemical and Quantum Chemical Study.

A series of pyridyl-substituted nitronyl nitroxides was synthesized and structurally characterized. A comprehensive magnetochemical and quantum chemical study of extended raw of the nitroxides with different substituents R in the pyridine fragment was performed. It was shown, that temperature-dependent magnetic properties are determined by the short contacts between nitroxide groups of adjacent molecules as well as between nitroxide group and methyl substituents in the pseudo axial positions of imidazoline fragments.

N-Alkylimidazol-5-yl-substituted Nitronyl Nitroxides and Their Mononuclear Cu(II) Complexes: Synthesis, Structure and Magnetic Properties.

A novel synthetic approach has been employed to synthesize a series of new nitronyl nitroxides: 2-(1-propyl-1H-imidazol-5-yl)- (L ), 2-(1-isopropyl-1H-imidazol-5-yl)- (L ) and 2-(1-butyl-1H-imidazol-5-yl)-4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazole-3-oxide-1-oxyl (L ). The reaction of Cu(hfac) with L in a 1 : 2 ratio yields mononuclear heterospin complexes [Cu(hfac) (L ) ] (L =L , L , L ), which have a similar crystal structure to the "jumping" crystals [Cu(hfac) (L ) ] that exhibit chemomechanical activity. It was shown that an increase in the alkyl substituent R leads to changes in the crystal packing of the molecules and the absence of chemomechanical activity.

Novel pyridyl-substituted nitronyl nitroxides as potential antiarrhythmic and hypotensive agents with low toxicity and enhanced stability in aqueous solutions.

This study explores the antiarrhythmic and hypotensive potential of pyridyl-substituted nitronyl nitroxides derivatives, uncovering the crucial role of a single carbon moiety of the pyridine cycle alongside radical and charged oxygen centers of the imidazoline fragment. Notably, the introduction of fluorine atoms diminished the antiarrhythmic effect, while the most potent derivatives featured the nitronyl nitroxide pattern positioned at the third site of the pyridine cycle. Gender-dependent responses were observed in lead compounds L and L, with L inducing temporary bradycardia and hypotension specifically in female rats, and L causing significant blood pressure reduction followed by rebound in females compared to milder effects in males.